Endothelial Function and Progenitor Cells in Acute Ischemic Stroke (EPCAS)
|ClinicalTrials.gov Identifier: NCT01289795|
Recruitment Status : Unknown
Verified January 2011 by Charite University, Berlin, Germany.
Recruitment status was: Recruiting
First Posted : February 4, 2011
Last Update Posted : February 4, 2011
|Condition or disease|
Endothelial dysfunction is a key component of atherosclerosis which contributes to the development of cardio- and cerebrovascular diseases. However, endothelial dysfunction (ED) is not established as a risk factor for ischemic stroke.
As a novelty the proposed trial investigates the following variety of indirect markers of endothelial function in acute ischemic stroke:
circulating endothelial progenitor cells (EPC), endothelial microparticles (EMP), ENDOPAT (RH- PAT ratio) in two regards:
- time after ischemic events (< 48h, Days 4-5, day 7 or at discharge)
- etiological stroke subtypes
It is not known whether these parameters are changed after acute cerebral ischemia and could possibly serve as specific target for treatment.
|Study Type :||Observational|
|Estimated Enrollment :||30 participants|
|Official Title:||Endothelial Function and Progenitor Cells in Acute Ischemic Stroke|
|Study Start Date :||July 2010|
|Estimated Primary Completion Date :||December 2011|
|Estimated Study Completion Date :||June 2012|
first-ever ischemic stroke
first-ever ischemic stroke according to the WHO definition
- Levels of cEPC [ Time Frame: <48h, day 4-5, discharge or day 7 ]Levels of cEPC (CD34+/CD133+/VEGF2R+/CD31) in % of mononuclear cells using flow cytometry with respect to stroke subtypes.
- Levels of EMP [ Time Frame: <48h, day 4-5, day 7 or discharge ]Levels of EMP (Annexin V+/CD31+; CD62E+) using flow cytometry with respect to stroke subtypes.
- ENDOPAT [ Time Frame: <48h, day 4-5,day 7 ]Digital pulse volume change (with RH PAT as non invasive measurement (PAT-ratio; ENDOPAT, Itamar Medical Ltd.) for non-invasive, peripheral endothelial function
Biospecimen Retention: Samples Without DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01289795
|Contact: Thomas Liman, MDfirstname.lastname@example.org|
|Contact: Matthias Endres, MDemail@example.com|
|Center for Stroke Research Berlin||Recruiting|
|Berlin, Germany, 10117|
|Contact: Thomas Liman, MD 004930450560643 firstname.lastname@example.org|
|Principal Investigator: Thomas Liman, MD|
|Principal Investigator:||Matthias Endres, MD||Center for Stroke Research Berlin|