Apolipoprotein E Gene and Functional MRI (fMRI)
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|ClinicalTrials.gov Identifier: NCT01287819|
Recruitment Status : Completed
First Posted : February 1, 2011
Last Update Posted : September 19, 2019
- Apolipoprotein E gene (ApoE) is the most important genetic factor for Alzheimer disease (AD) and an important genetic factor for outcome of brain injury situations.
- Function magnetic resonance imaging (fMRI) is a powerful tool for study of both brain regional functions and brain network.
- Study about genetic contribution on fMRI is an emerging concept, which will help on understanding about how the genetics affecting the brain function.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||200 participants|
|Official Title:||Polymorphisms of Apolipoprotein E Gene and the Presentation of Resting-state Functional MRI|
|Study Start Date :||May 2012|
|Actual Primary Completion Date :||April 17, 2013|
|Actual Study Completion Date :||April 18, 2013|
APOE4 (+) and APE4 (-)
APOE4 (+) 10 people APOE4 (-) 20 people from 200 participants
- amyloid load by amyloid-PET examination [ Time Frame: every 5 years ]The primary end point of this study is the quantity of amyloid load in brain. The amyloid load will be calculated based on the results of AV45 PET study. The comparison between mTBI and controls will be conducted by ANOVA test. The confounders include vascular risks for AD, such as hypertension, diabetes, and APOE genotypes, education.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01287819
|New Taipei City, Taiwan, 235|
|Principal Investigator:||Chaur-Jong Hu, M.D.||Taipei Medical University Shuang Ho Hospital|