Academia Sinica Investigator Award 2010
|ClinicalTrials.gov Identifier: NCT01287468|
Recruitment Status : Unknown
Verified January 2011 by Taipei Medical University WanFang Hospital.
Recruitment status was: Active, not recruiting
First Posted : February 1, 2011
Last Update Posted : February 1, 2011
|Condition or disease|
Ji-Hong Jhu (朱紀洪, Hospital President, M.D./surgeon) and Huey-Kong Sytwu (司徒惠康, M.D., Ph.D.) at the National Defense University Hospital. The investigators will then study the molecular signaling effect of specific phytocompounds already identified to confer in vivo (mouse), anti-tumor and anti-inflammatory activities, in primary/organoid cultures of human breast tumor cells under ex vivo conditions. Finally, the investigators intend to identify the key molecular regulators, immune-modulatory effectors of test stromal immune cells that are affected by the candidate phytomedicines, using molecular and cell biology assays to investigate the interplay between immune cells and tumor cells in the stromal tissues.
Our study is expected to reveal one or more highly specific, anti-inflammatory phytocompounds that mechanistically confer specific effects on stromal fibroblast or immune cell types, resulting in potent anti-tumor effects on test mammary carcinoma systems. Five Specific Aims are thus designed to investigate the immuno-modulating effects of specific medicinal constituents from TCM materials. The experimental findings obtained from this study would provide insights in the molecular, cellular and signaling mechanisms/effects of several medicinal phytocompounds that may have potential applications in chemoprevention or herbal medicine adjuvant treatment of human breast cancers.
|Study Type :||Observational|
|Estimated Enrollment :||415 participants|
|Official Title:||Academia Sinica Investigator Award 2010|
|Study Start Date :||June 2010|
|Estimated Study Completion Date :||December 2014|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01287468
|Taipei Medical University - WanFang Hospital|
|Principal Investigator:||Ning-Sun Yang||Academia Sinica, Taiwan|