Quantifying and Understanding the Signs and Symptoms of Fever

Study Description

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Brief Summary:

Background:

- Fever is a common symptom of illness, but it can involve many signs (a signal that something is not right in the body that can be seen by others, such as vomiting) and symptoms (a signal that something is not right in the body that are felt only by the person, such as pain) that may differ depending on the type of illness involved. Researchers are interested in studying individuals who have a fever to examine how often these signs and symptoms are experienced by patients.

Objectives:

- To identify and evaluate the signs and symptoms of fever and examine their frequency in individuals who have fever.

Eligibility:

- Individuals at least 8 years of age who are admitted to the NIH Clinical Center and have a fever (body temperature of at least 38 degrees Celsius/100.4 degrees Fahrenheit).

Design:

• Participants will be screened upon admission to the NIH Clinical Center.
• Researchers will review the Clinical Center admission records.
• Participants will complete a 15- to 20-minute survey with questions about how they are feeling and what symptoms they have experienced before, during and after an episode of fever.

Condition or disease
Fever

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Study Design

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Study Type :	Observational
Actual Enrollment :	99 participants
Observational Model:	Other
Time Perspective:	Prospective
Official Title:	Beyond Intuition: Quantifying and Understanding the Signs and Symptoms of Fever
Study Start Date :	January 13, 2011
Study Completion Date :	August 9, 2017

Groups and Cohorts

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Outcome Measures

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Primary Outcome Measures :

1. Symptoms of fever [ Time Frame: Throughout in patient admission ]

Eligibility Criteria

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Ages Eligible for Study:	18 Years to 100 Years (Adult, Senior)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	No

Criteria

• INCLUSION CRITERIA PHASE I:

Adult and pediatric medical-surgical patients hospitalized in the Clinical Center, NIH admitted to 3NE (oncology/ transplant), 3NW (surgical oncology) and 1NW (pediatrics).

Oriented to person, time and place at time of interview

Active fever (body temperature greater than or equal to 38.0 Celsius), treated or untreated, within the last 12 hours.

Willingness to participate in a short interview (15-20 minutes) about their symptoms

Understands and speaks English

Age 8 years and older

INCLUSION CRITERIA FOR STUDY OF FEBRILE ASSESSMENT TOOL:

Adult (18 years of age or greater) medical-surgical patients hospitalized at the Clinical Center and admitted to 3NW.

Oriented to person, time and place at time of admission

Willingness to be asked about their symptoms of fever during vital signs assessment

Understands and speaks English

INCLUSION CRITERIA PHASE II:

Inpatients admitted to the Clinical Center

Age 8 years and older

Contacts and Locations

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Locations

United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892

Sponsors and Collaborators

National Institutes of Health Clinical Center (CC)

Investigators

Principal Investigator:	Nancy Ames, R.N.	National Institutes of Health Clinical Center (CC)

More Information

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Publications:

Laupland KB. Fever in the critically ill medical patient. Crit Care Med. 2009 Jul;37(7 Suppl):S273-8. doi: 10.1097/CCM.0b013e3181aa6117. Review.

Chesnutt BK, Zamora MR, Kleinpell RM. Blood cultures for febrile patients in the acute care setting: too quick on the draw? J Am Acad Nurse Pract. 2008 Nov;20(11):539-46. doi: 10.1111/j.1745-7599.2008.00356.x. Review.

Bor DH, Makadon HJ, Friedland G, Dasse P, Komaroff AL, Aronson MD. Fever in hospitalized medical patients: characteristics and significance. J Gen Intern Med. 1988 Mar-Apr;3(2):119-25.

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Ames NJ, Powers JH, Ranucci A, Gartrell K, Yang L, VanRaden M, Leidy NK, Wallen GR. A systematic approach for studying the signs and symptoms of fever in adult patients: the fever assessment tool (FAST). Health Qual Life Outcomes. 2017 Apr 27;15(1):84. doi: 10.1186/s12955-017-0644-6.

Responsible Party:	National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:	NCT01287143 History of Changes
Other Study ID Numbers:	110083; 11-CC-0083
First Posted:	February 1, 2011
Last Update Posted:	October 6, 2017
Last Verified:	August 9, 2017

Keywords provided by National Institutes of Health Clinical Center (CC):

Fever; Signs and Symptoms; Febrile Assessment Tool (FAST)

Additional relevant MeSH terms:

Fever; Signs and Symptoms; Body Temperature Changes