Cancer Stem Cell Markers and Prognostic Markers in Circulating Tumor Cells
|ClinicalTrials.gov Identifier: NCT01286883|
Recruitment Status : Completed
First Posted : January 31, 2011
Last Update Posted : January 27, 2017
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||33 participants|
|Official Title:||Prevalence of Stem Cell and Prognostic Markers in Circulating Tumor Cells of Patients With Metastatic Colorectal Cancer Undergoing Chemotherapy|
|Actual Study Start Date :||February 2011|
|Actual Primary Completion Date :||February 2014|
|Actual Study Completion Date :||September 2014|
Laboratory studies will be performed at baseline; Cycle 1, Day 1; Cycle 1, Day 7; Cycle 2, Day 1; Cycle 3, Day 1; Cycle 4, Day 1; Cycle 6, Day 1; Cycle 12, Day 1.
- Primary endpoint: correlation of stem cell markers on CTCs with response to therapy [ Time Frame: 3 years ]Correlate the presence of stem cell markers and prognostic markers on circulating tumor cells with response to therapy for advanced colorectal cancer, as well as overall survival
- Secondary Outcome: Correlation of stem cell markers in primary tumors with stem cell markers in CTCs [ Time Frame: 3 years ]Evaluate the primary tumor if available for stem cell markers and prognostic markers. Perform genomic analysis of CTC DNA. Compare genomic analysis of primary tumor and CTC DNA. Evaluate CTC gene expression profiles and compare with primary tumor profiles. Evaluate emerging microfluidic devices in pilot studies that use drops of blood for CTC analysis.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01286883
|United States, Pennsylvania|
|Penn State Milton S. Hershey Medical Center|
|Hershey, Pennsylvania, United States, 17033|
|Principal Investigator:||Wafik S El-Deiry, MD, PhD||Penn State College of Medicine, Penn State Milton S. Hershey Medical Center|