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Immune Response After Booster Vaccination in HIV - Infected Patients Who Received Rabies Primary Vaccination

This study has been completed.
Information provided by (Responsible Party):
Suda Sibunruang, Queen Saovabha Memorial Institute Identifier:
First received: January 26, 2011
Last updated: October 19, 2015
Last verified: October 2015
Booster rabies vaccination in HIV - infected patients who have ever received rabies primary vaccination could improve their immune response to this kind of vaccine.

Condition Intervention
Biological: rabies vaccines on day 0 and 3

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Immune Response After Booster Vaccination in HIV - Infected Patients Who Ever Received Rabies Primary Vaccination

Resource links provided by NLM:

Further study details as provided by Suda Sibunruang, Queen Saovabha Memorial Institute:

Primary Outcome Measures:
  • Rabies Neutralizing Antibody Titers [ Time Frame: Day 360 ]

    Rabies Neutralizing Antibody titers(RNab)of HIV-infected patients who receive booster rabies vaccination would be measured by Rapid Fluorescent Focus Inhibition Test(RFFIT) method at day 0, 7, 14, 28, 90,180 and 360. RNab level above 0.5 IU/ml indicate acceptable protective antibody response.

    for 7 times in 1 year.

Enrollment: 33
Study Start Date: February 2011
Study Completion Date: December 2013
Primary Completion Date: December 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Rabies vaccines on day 0 and 3
Cell culture Rabies vaccines on day 0 and 3
Biological: rabies vaccines on day 0 and 3
All subjects would receive conventional intramuscular booster rabies vaccination on day 0 and 3. Their blood would be drawn for rabies neutralizing antibody on day 0,7,14,30,90,180,360

Detailed Description:
The investigators have learned from the previous studies that some HIV-infected patients especially those with low CD4+ T-lymphocyte count had poor antibody response to rabies vaccination. Because of the role of the memory B cell, the investigators hypothesized that primary rabies immunization in HIV-infected patients could rise rapid anamnestic antibody response to ones after booster vaccination in case of re-exposure of rabies occur despite of their immunocompromised state.

Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • HIV infected patients 18-60 years of age
  • Ever received primary rabies immunization

Exclusion Criteria:

  • currently have any active opportunistic infections
  • have received blood or blood product within previous 3 months
  • history of allergy to vaccine or any vaccine components
  • currently received anti-malarial drugs
  Contacts and Locations
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Please refer to this study by its identifier: NCT01286493

Queen Saovabha Memorial Institute
Bangkok, Thailand, 10330
Sponsors and Collaborators
Queen Saovabha Memorial Institute
Principal Investigator: Suda Sibunruang, MD Queen Saovabha Memorial Institute
  More Information

Additional Information:
Responsible Party: Suda Sibunruang, Principal investigator, Queen Saovabha Memorial Institute Identifier: NCT01286493     History of Changes
Other Study ID Numbers: RC5303
Study First Received: January 26, 2011
Results First Received: April 21, 2014
Last Updated: October 19, 2015

Keywords provided by Suda Sibunruang, Queen Saovabha Memorial Institute:
immune response

Additional relevant MeSH terms:
Rhabdoviridae Infections
Mononegavirales Infections
RNA Virus Infections
Virus Diseases
Immunologic Factors
Physiological Effects of Drugs processed this record on May 25, 2017