Impact of Bariatric Surgery on Epicardial Adipose Tissue and on Myocardial Function
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|ClinicalTrials.gov Identifier: NCT01284816|
Recruitment Status : Completed
First Posted : January 27, 2011
Last Update Posted : July 24, 2015
Growing evidence suggests that bariatric surgery is a relevant treatment for severely obese patients, especially those with metabolic complications, as it significantly reduces weight, hypertension and ameliorates glycemic control. Its action on adipose tissue distribution and in particular on epicardial adipose tissue EAT remains unknown. Whether metabolic improvement is associated with EAT reduction is also unknown.
The researchers thus investigated the effect of bariatric surgery on EAT in severely obese patients. The primary endpoint of this study was the change in EAT amount 6 months after bariatric surgery.
|Condition or disease||Intervention/treatment||Phase|
|Severely Obese Patients||Procedure: bariatric surgery||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||44 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Official Title:||Impact of Bariatric Surgery on Epicardial Adipose Tissue and on Myocardial Function|
|Study Start Date :||September 2010|
|Actual Primary Completion Date :||July 2015|
severely obese patients
35 patients addressed for severe obesity in the Endocrinology department of Marseille North Hospital before (V1) and 6 months (V2) after bariatric surgery
Procedure: bariatric surgery
The bariatric surgery is a relevant treatment for severely obese patients those with metabolic complications, as it significantly reduces weight, hypertension and ameliorates glycemic control.
- The change in EAT amount 6 months after bariatric surgery. [ Time Frame: 36 months ]We thus investigated the effect of bariatric surgery on EAT in severely obese patients.
- Evaluation of 3 parameters [ Time Frame: 36 months ]
- to evaluate the variation in myocardial, hepatic , pancreatic and triglyceride content
- to evaluate the variation in left ventricular function or myocardial function
- and to describe the relationships between changes in visceral abdominal fat, subcutaneous fat and epicardial fat
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01284816
|Marseille, France, 13|
|Principal Investigator:||Anne Dutour, Professor||AP-HM|