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Natural Killer Cells and Polycythemia Vera (Vaquez's Disease)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified September 2015 by Assistance Publique Hopitaux De Marseille.
Recruitment status was:  Active, not recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01284712
First Posted: January 27, 2011
Last Update Posted: October 1, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Assistance Publique Hopitaux De Marseille
  Purpose
Natural Killer cells (NK) are pivotal cells of innate immunity, that sense defective expression of HLA class I molecules and are complementary to specific cytotoxic T lymphocytes. A defect in NK cell cytotoxicity has been described in some hematopoietic malignancies such as acute myeloid leukemia, multiple myeloma, myelodysplastic syndroms. This defect is at least partially linked to a decreased or absent expression of some activating NK cell molecules, more particularly the so-called Natural Cytotoxicity Receptors (NCRs) NKp30, NKp44 and NKp46. Some old publications have demonstrated defective NK cytotoxicity in myeloproliferative syndroms (chronic myeloid leukemia, primary thrombocytosis, polycythemia vera). The investigators more particularly focused their attention on polycythemia vera (Vaquez's disease), a myeloproliferative disease characterized by the recently describet mutation V617F of the JAK2 tyrosine kinase. The investigators will precise the mechanisms leading to this cytotoxicity defect, the investigators also will evaluate the implication of V617F mutation on NK physiology, and will study the interactions between NK cells and hematopoietic progenitors.

Condition Intervention
Polycythemia Vera Biological: blood sample

Study Type: Observational
Study Design: Time Perspective: Prospective

Resource links provided by NLM:


Further study details as provided by Assistance Publique Hopitaux De Marseille:

Primary Outcome Measures:
  • To describe immunologic anomalies in polycythemia vera [ Time Frame: 2 years ]

Estimated Enrollment: 27
Study Start Date: July 2009
Primary Completion Date: July 2013 (Final data collection date for primary outcome measure)
Intervention Details:
    Biological: blood sample
    blood sample coming from therapeutic bleeding in hospital
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
VAQUEZ'S DISEASE
Criteria

Inclusion Criteria:

  • Polycythemia vera
  • Treatment by therapeutic bleedings
  • No cytotoxic treatment during the previous six months

Exclusion Criteria:

  • No Polycythemia vera
  • No treatment by therapeutic bleedings
  • Cytotoxic treatment during the previous six months
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01284712


Locations
France
Assistance Publique - Hopitaux de Marseille
Marseille, France
Sponsors and Collaborators
Assistance Publique Hopitaux De Marseille
Investigators
Principal Investigator: Regis Costello Assistance Publique Hopitaux De Marseille
  More Information

Responsible Party: Assistance Publique Hopitaux De Marseille
ClinicalTrials.gov Identifier: NCT01284712     History of Changes
Other Study ID Numbers: 2009/16
2009-A00395-52
First Submitted: August 3, 2009
First Posted: January 27, 2011
Last Update Posted: October 1, 2015
Last Verified: September 2015

Keywords provided by Assistance Publique Hopitaux De Marseille:
treatment by bleedings

Additional relevant MeSH terms:
Polycythemia
Polycythemia Vera
Hematologic Diseases
Bone Marrow Neoplasms
Hematologic Neoplasms
Neoplasms by Site
Neoplasms
Bone Marrow Diseases
Myeloproliferative Disorders