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Renal Tubular Acidosis in Incident Renal Transplant Recipients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01283880
Recruitment Status : Unknown
Verified January 2011 by Universitaire Ziekenhuizen Leuven.
Recruitment status was:  Recruiting
First Posted : January 26, 2011
Last Update Posted : May 30, 2012
Information provided by (Responsible Party):
Universitaire Ziekenhuizen Leuven

Brief Summary:
Metabolic acidosis is a common complication in incident renal transplant recipients. Protracted acidosis may be associated with osteoporosis, inflammation, negative protein balance and malnutrition, and last but not least may cause renal dysfunction. Preliminary data indicate an increased prevalence of nephrocalcinosis in renal transplant biopsies of incident patients presenting with metabolic acidosis. The present study aims (1)evaluate the prevalence and type of renal tubular acidosis (RTA) in incident renal transplant recipients and to identify clinical correlates and (2) to find associations between RTA, nephrolithiasis and nephrocalcinosis

Condition or disease
Renal Transplant Disorder

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Study Type : Observational
Estimated Enrollment : 50 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Renal Tubular Acidosis in Incident Renal Transplant Recipients
Study Start Date : May 2012
Estimated Primary Completion Date : June 2013
Estimated Study Completion Date : June 2013

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
renal transplant recipients

Inclusion Criteria:

  • Recipient of a single kidney transplant included in the protocol biopsy program.
  • eGFR > 30 ml/min
  • Age ≥ 18 years
  • Written informed consent

Exclusion Criteria:

  • none

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01283880

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Contact: Pieter Evenepoel, MD 003216344580

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University Hospitals Leuven Recruiting
Leuven, Belgium, 3000
Principal Investigator: Pieter Evenepoel, MD         
Sponsors and Collaborators
Universitaire Ziekenhuizen Leuven
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Principal Investigator: Pieter Evenepoel, MD Universitaire Ziekenhuizen Leuven

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Responsible Party: Universitaire Ziekenhuizen Leuven Identifier: NCT01283880     History of Changes
Other Study ID Numbers: ML6919
First Posted: January 26, 2011    Key Record Dates
Last Update Posted: May 30, 2012
Last Verified: January 2011
Keywords provided by Universitaire Ziekenhuizen Leuven:
metabolic acidosis
renal tubular acidosis
Additional relevant MeSH terms:
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Acidosis, Renal Tubular
Acid-Base Imbalance
Metabolic Diseases
Renal Tubular Transport, Inborn Errors
Kidney Diseases
Urologic Diseases
Metabolism, Inborn Errors
Genetic Diseases, Inborn