Acute Heart Health Benefits of Whole Grain Barley and Oats in Healthy Men and Women
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01283672|
Recruitment Status : Completed
First Posted : January 26, 2011
Last Update Posted : July 18, 2011
|Condition or disease||Intervention/treatment||Phase|
|Cardiovascular Disease||Other: Controlled diet with whole grain barley, whole grain oats, or low grain diet||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||18 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Double (Participant, Investigator)|
|Study Start Date :||January 2011|
|Actual Primary Completion Date :||April 2011|
|Actual Study Completion Date :||April 2011|
Other: Controlled diet with whole grain barley, whole grain oats, or low grain diet
- Lipid Tolerance Test [ Time Frame: After 3 consecutive days of controlled feeding. ]Participants will come in after a 12-hour fast for a lipid tolerance test. Specifically, participants will consume a treatment breakfast meal and blood samples will be collected 30, 60, 90, 120, 150, 180, 210, 240, 270, 300, 360, and 420 minutes following ingestion of the treatment meal.
- EndoPAT [ Time Frame: After 3 consecutive days of controlled feeding ]Endothelial function will be assessed by measuring endothelium-dependent flow mediated dilation of the peripheral bed (EndoPAT, Itamar Medical, Israel). Immediately after the test, a blood sample will be collected for measurement of serum triglycerides.
- Genetic testing [ Time Frame: After 3 consecutive days of controlled feeding ]Blood will be used to test for genetic traits that may influence nutrient metabolism and also traits reflecting the mechanisms that may be influenced by the intervention.
- Microarray and targeted gene expression testing [ Time Frame: After 3 consecutive days of controlled feeding ]Blood samples will be used to test how the intervention affects gene expression. Global gene expression will be performed for a complete survey of the RNA response to the intervention, and targeted gene expression will be performed to confirm the findings of the global gene expression analysis.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01283672
|United States, Maryland|
|US Department of Agriculture Beltsville Human Nutrition Research Center|
|Beltsville, Maryland, United States, 20705|
|Principal Investigator:||David J Baer, PhD||US Department of Agriculture|