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Reference Values for Pulse Induced Continuous Cardiac Output (PiCCO) Variables in Children

This study has been completed.
Information provided by (Responsible Party):
Gunnar Bentsen, Oslo University Hospital Identifier:
First received: January 17, 2011
Last updated: August 29, 2016
Last verified: August 2016
Pulse induced continuous cardiac output (PiCCO) is an established technology for measurement of advanced hemodynamic variables in critically ill patients. PiCCO is approved and designed also for use in children, but there is a lack of documentation of reference values in children not suffering from a critical illness. The goal of this study is to establish such values.

Reference Values

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Reference Values for Cardiac Output and Blood Volume Variables in Children With Normal Cardiac Function Measured Under General Anesthesia.

Further study details as provided by Gunnar Bentsen, Oslo University Hospital:

Primary Outcome Measures:
  • Reference values for PiCCO variables [ Time Frame: 18 months ]

Enrollment: 31
Study Start Date: January 2011
Study Completion Date: September 2015
Primary Completion Date: February 2014 (Final data collection date for primary outcome measure)
Children 0 - 15 years
Children undergoing neurosurgery in general anesthesia


Ages Eligible for Study:   up to 15 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
40 children age 0 - 15 years undergoing major neurosurgery under general anesthesia

Inclusion Criteria:

  • Age < 15 years
  • Scheduled for major neurosurgery in general anesthesia

Exclusion Criteria:

  • Cardiac disease
  • Infection / sepsis
  Contacts and Locations
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Please refer to this study by its identifier: NCT01283529

Oslo University Hospital, Rikshospitalet
Oslo, Norway, 0871
Sponsors and Collaborators
Oslo University Hospital
Principal Investigator: Gunnar Bentsen, MD PhD Oslo University Hospital
  More Information

Responsible Party: Gunnar Bentsen, Consultant, Oslo University Hospital Identifier: NCT01283529     History of Changes
Other Study ID Numbers: 2010/27693
2010/2576-4 ( Other Identifier: Ethics commitee )
Study First Received: January 17, 2011
Last Updated: August 29, 2016

Keywords provided by Gunnar Bentsen, Oslo University Hospital:
Intrathoracal blood volume
Cardiac output
Children processed this record on June 23, 2017