Reference Values for Pulse Induced Continuous Cardiac Output (PiCCO) Variables in Children

This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
Gunnar Bentsen, Oslo University Hospital Identifier:
First received: January 17, 2011
Last updated: April 21, 2015
Last verified: April 2015
Pulse induced continuous cardiac output (PiCCO) is an established technology for measurement of advanced hemodynamic variables in critically ill patients. PiCCO is approved and designed also for use in children, but there is a lack of documentation of reference values in children not suffering from a critical illness. The goal of this study is to establish such values.

Reference Values

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Reference Values for Cardiac Output and Blood Volume Variables in Children With Normal Cardiac Function Measured Under General Anesthesia.

Further study details as provided by Oslo University Hospital:

Primary Outcome Measures:
  • Reference values for PiCCO variables [ Time Frame: 18 months ] [ Designated as safety issue: No ]

Estimated Enrollment: 40
Study Start Date: January 2011
Estimated Study Completion Date: September 2015
Primary Completion Date: February 2014 (Final data collection date for primary outcome measure)
Children 0 - 15 years
Children undergoing neurosurgery in general anesthesia


Ages Eligible for Study:   up to 15 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
40 children age 0 - 15 years undergoing major neurosurgery under general anesthesia

Inclusion Criteria:

  • Age < 15 years
  • Scheduled for major neurosurgery in general anesthesia

Exclusion Criteria:

  • Cardiac disease
  • Infection / sepsis
  Contacts and Locations
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Please refer to this study by its identifier: NCT01283529

Oslo University Hospital, Rikshospitalet
Oslo, Norway, 0871
Sponsors and Collaborators
Oslo University Hospital
Principal Investigator: Gunnar Bentsen, MD PhD Oslo University Hospital
  More Information

Responsible Party: Gunnar Bentsen, Consultant, Oslo University Hospital Identifier: NCT01283529     History of Changes
Other Study ID Numbers: 2010/27693  2010/2576-4 
Study First Received: January 17, 2011
Last Updated: April 21, 2015
Health Authority: Norway: Regional commitee for medical for medical and health reserch etics
Norway: Oslo University Hospital, Medical reserch department

Keywords provided by Oslo University Hospital:
Intrathoracal blood volume
Cardiac output
Children processed this record on May 01, 2016