Hydrogen Sulfide Detoxification and Butyrate Metabolism in Ulcerative Colitis

This study has been completed.
Information provided by:
Katholieke Universiteit Leuven
ClinicalTrials.gov Identifier:
First received: January 24, 2011
Last updated: January 25, 2011
Last verified: January 2011
The purpose of this study is to evaluate the relation between sulphide detoxification and butyrate metabolism at the level of gene expression and enzyme activity in ulcerative colitis patients and healthy controls.

Ulcerative Colitis

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Impact of the Mucosal Detoxification Mechanism of Hydrogen Sulphide on the Oxidation Pathway of Butyrate in Ulcerative Colitis

Resource links provided by NLM:

Further study details as provided by Katholieke Universiteit Leuven:

Biospecimen Retention:   Samples With DNA
colon tissue

Enrollment: 106
Study Start Date: October 2008
Study Completion Date: December 2010
Healthy controls
Ulcerative colitis


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
IBD patients clinic (Universitaire Ziekenhuizen Leuven)

Inclusion Criteria:

- Ulcerative colitis patients: patients diagnosed with ulcerative colitis

Exclusion Criteria:

  • Healthy controls: no diagnosis of inflammatory bowel diseases
  • Intake of antibiotics in the last month before the study
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01282905

Leuven, Belgium
Sponsors and Collaborators
Katholieke Universiteit Leuven
Principal Investigator: Kristin Verbeke, PhD Katholieke Universiteit Leuven
  More Information

Responsible Party: Prof. Kristin Verbeke, KULeuven
ClinicalTrials.gov Identifier: NCT01282905     History of Changes
Other Study ID Numbers: ML3999 
Study First Received: January 24, 2011
Last Updated: January 25, 2011
Health Authority: Belgium: Ethics Committee

Additional relevant MeSH terms:
Colitis, Ulcerative
Colonic Diseases
Digestive System Diseases
Gastrointestinal Diseases
Inflammatory Bowel Diseases
Intestinal Diseases
Pathologic Processes
Hydrogen Sulfide
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Pharmacologic Actions
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on May 02, 2016