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Hydrogen Sulfide Detoxification and Butyrate Metabolism in Ulcerative Colitis

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ClinicalTrials.gov Identifier: NCT01282905
Recruitment Status : Completed
First Posted : January 25, 2011
Last Update Posted : January 26, 2011
Sponsor:
Information provided by:

Study Description
Brief Summary:
The purpose of this study is to evaluate the relation between sulphide detoxification and butyrate metabolism at the level of gene expression and enzyme activity in ulcerative colitis patients and healthy controls.

Condition or disease
Ulcerative Colitis

Study Design

Study Type : Observational
Actual Enrollment : 106 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Impact of the Mucosal Detoxification Mechanism of Hydrogen Sulphide on the Oxidation Pathway of Butyrate in Ulcerative Colitis
Study Start Date : October 2008
Study Completion Date : December 2010

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Groups and Cohorts

Group/Cohort
Healthy controls
Ulcerative colitis


Outcome Measures

Biospecimen Retention:   Samples With DNA
colon tissue

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
IBD patients clinic (Universitaire Ziekenhuizen Leuven)
Criteria

Inclusion Criteria:

- Ulcerative colitis patients: patients diagnosed with ulcerative colitis

Exclusion Criteria:

  • Healthy controls: no diagnosis of inflammatory bowel diseases
  • Intake of antibiotics in the last month before the study
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01282905


Locations
Belgium
KULeuven
Leuven, Belgium
Sponsors and Collaborators
Katholieke Universiteit Leuven
Investigators
Principal Investigator: Kristin Verbeke, PhD Katholieke Universiteit Leuven
More Information

Responsible Party: Prof. Kristin Verbeke, KULeuven
ClinicalTrials.gov Identifier: NCT01282905     History of Changes
Other Study ID Numbers: ML3999
First Posted: January 25, 2011    Key Record Dates
Last Update Posted: January 26, 2011
Last Verified: January 2011

Additional relevant MeSH terms:
Colitis
Ulcer
Colitis, Ulcerative
Gastroenteritis
Gastrointestinal Diseases
Digestive System Diseases
Colonic Diseases
Intestinal Diseases
Pathologic Processes
Inflammatory Bowel Diseases
Hydrogen Sulfide
Gasotransmitters
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs