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Trial record 5 of 250 for:    Recruiting, Not yet recruiting, Available Studies | "Lower Urinary Tract Symptoms"

Bladder Wall Blood Perfusion Pattern and Sexual Dysfunction in Female Patients With Lower Urinary Tract Symptoms, and the Association of That Perfusion Pattern and Therapeutic Efficacy of Antimuscarincs for Female Overactive Bladder Syndrome.

This study is currently recruiting participants.
Verified September 2016 by Sheng-Mou Hsiao, Far Eastern Memorial Hospital
Sponsor:
ClinicalTrials.gov Identifier:
NCT01282840
First Posted: January 25, 2011
Last Update Posted: September 7, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Collaborator:
National Science Council, Taiwan
Information provided by (Responsible Party):
Sheng-Mou Hsiao, Far Eastern Memorial Hospital
  Purpose
Overactive bladder syndrome (OAB) affects around 17 % of female population. However, the etiology of OAB is complicated and unclear in many aspects. Bladder wall thickness had been reported to be strongly associated with OAB, but its use as a screening tool remains controversial. Besides, few studies reported patterns of sexual dysfunction in female patients with lower urinary tract symptoms (LUTS). Therefore the aims of our study were to analyze the bladder wall blood perfusion pattern in female LUTS patients, the association of between the bladder wall blood perfusion pattern and the efficacy of anti-muscarinic treatment for female OAB, and the patterns of sexual dysfunction in the female LUTS patients.

Condition Intervention
Lower Urinary Tract Symptoms Drug: Tolterodine SR

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment

Resource links provided by NLM:


Further study details as provided by Sheng-Mou Hsiao, Far Eastern Memorial Hospital:

Primary Outcome Measures:
  • Blood flow pattern after antimuscarinics [ Time Frame: 12 weeks ]

Secondary Outcome Measures:
  • Blood flow patterns between different LUTS subgroups [ Time Frame: 1 day ]

Estimated Enrollment: 300
Study Start Date: July 2010
Estimated Study Completion Date: December 2017
Estimated Primary Completion Date: July 2017 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Bladder wall blood perfusion pattern Drug: Tolterodine SR
Tolterodine SR 4 mg qd

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 99 Years   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • all cases are female patients with lower urinary tract symptoms

Exclusion Criteria:

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01282840


Locations
Taiwan
Far Eastern Memorial Hospital Recruiting
Pan-Chiao, Taiwan
Contact: Hsiao Sheng Mou, MD    +886-2-89667000 ext 124    smhsiao2@gmail.com   
Sponsors and Collaborators
Far Eastern Memorial Hospital
National Science Council, Taiwan
  More Information

Responsible Party: Sheng-Mou Hsiao, Chief, Department of Obstetrics & Gynecology, Far Eastern Memorial Hospital
ClinicalTrials.gov Identifier: NCT01282840     History of Changes
Other Study ID Numbers: 099049-F
First Submitted: January 23, 2011
First Posted: January 25, 2011
Last Update Posted: September 7, 2016
Last Verified: September 2016

Keywords provided by Sheng-Mou Hsiao, Far Eastern Memorial Hospital:
LUTS

Additional relevant MeSH terms:
Lower Urinary Tract Symptoms
Urological Manifestations
Signs and Symptoms
Tolterodine Tartrate
Muscarinic Antagonists
Cholinergic Antagonists
Cholinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Urological Agents