Dual-energy CT in Detecting Bone Marrow Edema of Vertebral Compression Fractures
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01281826|
Recruitment Status : Unknown
Verified January 2011 by National Cheng-Kung University Hospital.
Recruitment status was: Recruiting
First Posted : January 24, 2011
Last Update Posted : February 11, 2011
The purpose of this study is to
- Assess bone marrow edema within the VCF by use of a DE CT virtual noncalcium image compared with MR imaging as standard reference.
- Evaluate parameters related to the BME of the collapsed vertebral body on DE CT virtual noncalcium images, such as the morphologic signs, visual qualitative detection, and quantitative values.
|Condition or disease|
|Compression Fracture of Thoracic Vertebral Body Spinal Compression Fracture|
Patients with multiple compression fractures and in those with chronic fracture, determining which vertebra to treat is frequently difficult. In such patients, the treatment location is commonly determined from findings at imaging, which includes magnetic resonance (MR) imaging, bone scintigraphy, and computed tomography (CT).
The bone marrow edema (BME) in acute/subacute VCFs is useful in determining the vertebra that is to be treated.
MR imaging provides information on anatomic vertebral collapse and the loss of normal T1 high signal intensity from the marrow space of vertebrae with acute fractures. Loss of normal T1 high signal intensity indicates the presence of BME, which is the important sign for the PVP treatment of VCFs.
Dual-energy (DE) CT has been used to create a virtual unenhanced scan by subtracting iodine from contrast agent-enhanced CT examinations.We expect that the same technique can be used to calculate a virtual noncalcium image from an unenhanced image, which makes bone marrow accessible for CT diagnosis.
|Study Type :||Observational|
|Estimated Enrollment :||70 participants|
|Official Title:||Use of Dual-energy CT in Detecting Bone Marrow Edema of Vertebral Compression Fractures|
|Study Start Date :||January 2011|
|Estimated Primary Completion Date :||December 2011|
|Estimated Study Completion Date :||December 2011|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01281826
|Contact: Chien-Kuo Wang||886-6-2353535 ext firstname.lastname@example.org|
|National Cheng-Kung University Hospital||Recruiting|
|Contact: Chien-Kuo Wang 886-6-2353535 ext 2491 email@example.com|
|Study Chair:||Chien-Kuo Wang||Department of Diagnostic Radiology Cheng Kung University Medicial Center|