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Dual-energy CT in Detecting Bone Marrow Edema of Vertebral Compression Fractures

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01281826
Recruitment Status : Unknown
Verified January 2011 by National Cheng-Kung University Hospital.
Recruitment status was:  Recruiting
First Posted : January 24, 2011
Last Update Posted : February 11, 2011
Information provided by:
National Cheng-Kung University Hospital

Brief Summary:

The purpose of this study is to

  1. Assess bone marrow edema within the VCF by use of a DE CT virtual noncalcium image compared with MR imaging as standard reference.
  2. Evaluate parameters related to the BME of the collapsed vertebral body on DE CT virtual noncalcium images, such as the morphologic signs, visual qualitative detection, and quantitative values.

Condition or disease
Compression Fracture of Thoracic Vertebral Body Spinal Compression Fracture

Detailed Description:

Patients with multiple compression fractures and in those with chronic fracture, determining which vertebra to treat is frequently difficult. In such patients, the treatment location is commonly determined from findings at imaging, which includes magnetic resonance (MR) imaging, bone scintigraphy, and computed tomography (CT).

The bone marrow edema (BME) in acute/subacute VCFs is useful in determining the vertebra that is to be treated.

MR imaging provides information on anatomic vertebral collapse and the loss of normal T1 high signal intensity from the marrow space of vertebrae with acute fractures. Loss of normal T1 high signal intensity indicates the presence of BME, which is the important sign for the PVP treatment of VCFs.

Dual-energy (DE) CT has been used to create a virtual unenhanced scan by subtracting iodine from contrast agent-enhanced CT examinations.We expect that the same technique can be used to calculate a virtual noncalcium image from an unenhanced image, which makes bone marrow accessible for CT diagnosis.

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Study Type : Observational
Estimated Enrollment : 70 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Use of Dual-energy CT in Detecting Bone Marrow Edema of Vertebral Compression Fractures
Study Start Date : January 2011
Estimated Primary Completion Date : December 2011
Estimated Study Completion Date : December 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Edema Fractures

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients are recruited from Department of Orthopedics between january 2011 and december 2011.

Inclusion Criteria:

  • Compression fractures (thoracic and lumbar vertebrae)

Exclusion Criteria:

  • Age less than 18 years
  • Pregnancy
  • Any contraindications to MR imaging.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01281826

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Contact: Chien-Kuo Wang 886-6-2353535 ext 2491

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National Cheng-Kung University Hospital Recruiting
Tainan, Taiwan
Contact: Chien-Kuo Wang    886-6-2353535 ext 2491   
Sponsors and Collaborators
National Cheng-Kung University Hospital
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Study Chair: Chien-Kuo Wang Department of Diagnostic Radiology Cheng Kung University Medicial Center
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Responsible Party: Chien-Kuo Wang/Department of Diagnostic Radiology, National Cheng-Kung University Hospital Identifier: NCT01281826    
Other Study ID Numbers: BR-99-093
First Posted: January 24, 2011    Key Record Dates
Last Update Posted: February 11, 2011
Last Verified: January 2011
Additional relevant MeSH terms:
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Fractures, Bone
Fractures, Compression
Wounds and Injuries