Influence of Acid Reflux on Stromal Epithelial Interaction in Barrett's Esophagus (CR20)
The purpose of this study is to determine the association between acid reflux and cell changes in Barrett's esophagus.
Specific aim 1: To test the hypothesis that controlled acid reflux is associated with lesser degree of stromal activation.
Specific aim 2: To test the hypothesis that stromal fibroblast derived growth factors drive BE epithelial proliferation.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Influence of Acid Reflux on Stromal Epithelial Interaction in Barrett's Esophagus|
- activated myofibroblasts [ Time Frame: 6 months ] [ Designated as safety issue: No ]The primary end point for the study will be the proportion of patients with activated myofibroblasts (defined as positive staining for SMA and vimentin with negative staining for Desmin, in > 50% of subepithelial myofibroblasts). This primary end point will be compared between the group with controlled acid reflux and the group without acid reflux.
Biospecimen Retention: Samples With DNA
Tissue specimens from Barrett's esophagus
|Study Start Date:||October 2008|
|Study Completion Date:||June 2011|
|Primary Completion Date:||June 2011 (Final data collection date for primary outcome measure)|
Those with barrett's esophagus
Those with barrett's esophagus: no dysplasia or low grade dysplasia
Procedure: 24 hour pH study and upper endoscopy (EGD)
All subjects enrolled will undergo 24 hour pH followed by EGD.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01281618
|United States, Minnesota|
|Rochester, Minnesota, United States, 55905|