Bleeding Prediction in Patients Following Cardiac Surgery Using Whole Blood Aggregometry and Thromboelastometry
|ClinicalTrials.gov Identifier: NCT01281397|
Recruitment Status : Terminated (After 148 patients enrolled, interim analysis revealed positive results in regard to primary hypothesis.)
First Posted : January 21, 2011
Last Update Posted : December 3, 2014
Use of whole blood impedance aggregometry and rotational thromboelastometry can reveal useful data about platelet function and viscoelastic properties of blood clot in patients undergoing cardiac surgery.
The purpose of this study is to clarify whether it is possible to predict patients on excessive risk of perioperative bleeding using whole blood impedance aggregometry and rotational thromoelastometry.
Antiplatelet therapy is the cornerstone in treatment of patients with coronary artery disease. Another research goal is to determine the degree of response to antiplatelet therapy before and after surgery and to investigate whether patients by level of response to antiplatelet therapy before surgery have a higher risk of perioperative bleeding.
|Condition or disease|
|Heart Disease Coronary Artery Disease Aortic Valve Disease Mitral Valve Disease|
|Study Type :||Observational|
|Actual Enrollment :||148 participants|
|Official Title:||Bleeding Prediction in Patients Undergoing Cardiac Surgery Using Whole Blood Impedance Aggregometry and Rotational Thromboelastometry|
|Study Start Date :||August 2009|
|Primary Completion Date :||January 2011|
|Study Completion Date :||January 2011|
Patients undergoing elective cardiac surgery
Patients undergoing elective cardiac surgery will be enrolled in study. Data about antiplatelet therapy ingestion prior to surgery will be included.
- Chest tube output in first 24 hours [ Time Frame: 24 hours after surgical procedure ]
- Allogenic blood products transfusion [ Time Frame: 7 days after surgery including the day of surgery ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01281397
|University hospital center Zagreb- Rebro|
|Zagreb, Croatia, 10000|
|Principal Investigator:||Mate Petricevic, M.D.||University hospital center Zagreb- Rebro|
|Study Chair:||Bojan Biocina, M.D., Ph.D.||University hospital center Zagreb - Rebro|