Effect of NAVA on Duration of Weaning in Difficult to Wean Patients
|ClinicalTrials.gov Identifier: NCT01280773|
Recruitment Status : Completed
First Posted : January 21, 2011
Last Update Posted : August 4, 2016
|Condition or disease||Intervention/treatment||Phase|
|Weaning||Device: Neurally adjusted ventilatory assist||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||91 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Department of Critical Care Medicine, Nanjing Zhong-Da Hospital, Southeast University School of Medicine, China; Department of Critical Care Medicine St. Michaels's Hospital, University of Toronto, Canada|
|Study Start Date :||September 2011|
|Actual Primary Completion Date :||July 2016|
|Actual Study Completion Date :||July 2016|
No Intervention: PSV weaning
Patinens in the PSV group will be weaned using PSV mode.
Experimental: NAVA weaning
Patients in NAVA group will eb weaned using NAVA mode.
Device: Neurally adjusted ventilatory assist
Neurally adjusted ventilatory assist (NAVA) was delivered by a SVi ventilator. NAVA utilizes EAdi, a reflection of the neural respiratory output to diaphragm, as its primary source to trigger and cycle-off assist in synchrony with neural inspiratory efforts.
Other Name: NAVA
- Duration of weaning [ Time Frame: 48h after extubation ]duration of weaning was defined as time from study enrollment to extubation.
- Extubation rate [ Time Frame: 48h after extubation or 30 day after enrollment ]Extubation rate was defined as the percentage of patients with successful weaning.
- diaphragmatic function [ Time Frame: At 8 am daily before extubatiuon ]Diaphragmatic function was measured by neuro-ventilatory efficiency (NVE), a ratio of tidal volume to diaphragm electrical activity (Vt/EAdi), and neuro-mechanical efficiency (NME), a ratio of airway pressure to EAdi(Paw/EAdi) during airway occlusion.
- Patient ventilator asynchrony [ Time Frame: At 8 am daily until extubation ]Time delay between neuro inspiration and ventilator delivery. Time delay between neuro expiration and ventilator cycle-off.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01280773
|Nanjing Zhong-Da Hospital|
|Nanjing, Jiangsu, China, 210009|
|Study Director:||Haibo Qiu, PhD,MD||Southeast University|