Analysis of Drug-drug Interaction Alert Based on Multicenter Clinical Database
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|ClinicalTrials.gov Identifier: NCT01280422|
Recruitment Status : Completed
First Posted : January 20, 2011
Last Update Posted : January 20, 2011
The doctor's overridden rate for Drug-drug interaction (DDI) alert systems was 85-95% in foreign and there was more than 90% overridden rate in Taiwan. Why DDI alerts systems which spent much time and money to establish could not use medicinal information to increase drug safety? One of the reasons which induced to override was that health care thought there were too much DDI alerts and high false alerts.
The difference between DDI alert systems from pharmacists to confirm drug-drug interaction was that pharmacists not only confirmed ordering drug at the same time but also checked the other drug information such as frequency, rote and refill etc. Therefore, DDI alert systems which were established by drug code alone would induce a lot of false alerts.
In order to study how much false alert rate in drug-drug interactions, this research selected most common drug-drug interaction which was antacids and antibiotics. Antacids were most self-payment so this research needed to analyze ROCDR (Establishing a Multi-Center, Longitudinal, Research-Oriented Clinical Data Repository for Clinical Research). The aim was to study how many drug-drug interactions and false alerts from antacids and antibiotics and analyze the difference in different department. Finally, proposing advice and assessment for building drug-drug interaction alerts system to strength drug information system and increase drug safety.
|Condition or disease|
|Drug Interaction Alert|
|Study Type :||Observational|
|Actual Enrollment :||67128927 participants|
|Official Title:||Analysis of Drug-drug Interaction Alert Based on Multicenter Clinical Database|
|Study Start Date :||February 2010|
|Actual Study Completion Date :||August 2010|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01280422
|Taipei Medical University - WanFang Hospital|
|Principal Investigator:||Yu-Chuan Li||Taipei Medical University WanFang Hospital|