Detection of Vascular Injury in Diabetes Through Eye and Nailfold Data (DIVIDEND) - A Pilot Study (DIVIDEND)
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|ClinicalTrials.gov Identifier: NCT01279928|
Recruitment Status : Completed
First Posted : January 20, 2011
Last Update Posted : January 25, 2011
This project aimed to explore novel methods of detecting small blood vessel disease in a paediatric population with type 1 diabetes mellitus. To do this the techniques of Nailfold capillaroscopy, laser Doppler flowmetry, retinal (eye) vessel analysis and 24-hr Ambulatory Blood Pressure Monitoring were used. Each of these techniques investigated different areas of small blood vessels around the body.
It was hypothesized that in a paediatric population with type 1 diabetes mellitus the novel investigations would be associated with small blood vessel disease and that widespread changes to these blood vessels would be detected through associations between the different novel investigations.
|Condition or disease||Intervention/treatment|
|Type 1 Diabetes Mellitus||Procedure: Video Nailfold Capillaroscopy Device: Ambulatory 24 hr Blood Pressure Monitoring Procedure: Fundoscopy of eyes Procedure: Laser Doppler Flowmetry|
|Study Type :||Observational|
|Actual Enrollment :||26 participants|
|Official Title:||Detection of Vascular Injury in Diabetes Through Eye and Nailfold Data (DIVIDEND) - A Pilot Study|
|Study Start Date :||March 2010|
|Actual Primary Completion Date :||September 2010|
|Actual Study Completion Date :||October 2010|
Type 1 Diabetes Paediatric
Paediatric patients aged 8-18 with diagnosed Diabetes Mellitis Type 1 attending paediatric clinic at John Hunter Hospital.
Procedure: Video Nailfold Capillaroscopy
Single session of video Nailfold Capillaroscopy wit KKK technologyDevice: Ambulatory 24 hr Blood Pressure Monitoring
24 hr upper arm cuff measurement of Blood PressureProcedure: Fundoscopy of eyes
examination of microvascular health of eye with the use of opthalmoscopeProcedure: Laser Doppler Flowmetry
Examination of vascular flow
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01279928
|Australia, New South Wales|
|John Hunter Children's Hospital|
|New Lambton, New South Wales, Australia, 2305|
|Principal Investigator:||Rani Bhatia, MD||John Hunter Children's Hospital|