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Aortic Stiffness in Chronic Kidney Disease Stage 2 to 4

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01279460
First Posted: January 19, 2011
Last Update Posted: January 19, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Department of Nephrology, Klinikum rechts der Isar, München
Information provided by:
Technische Universität München
  Purpose
This study aimed to investigate in a cohort with chronic kidney disease the longitudinal relationship between aortic stiffness and renal function and mortality.

Condition
Decline in Renal Function

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Evaluation of Aortic Stiffness in CKD II to IV

Resource links provided by NLM:


Further study details as provided by Technische Universität München:

Primary Outcome Measures:
  • combined renal end-point (>25% decline in renal function or start of renal replacement therapy) [ Time Frame: 24 months ]

Secondary Outcome Measures:
  • mortality [ Time Frame: 24 months ]

Enrollment: 167
Study Start Date: October 2007
Study Completion Date: December 2010
Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts
CKD Cohort of patients with renal insufficiency
patients with renal insufficiency grade II-IV

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients were enrolled in a prospective study of vascular stiffness and CV risk in patients with CKD stages 2 to 4. They were predominantly recruited from outpatients attending nephrology clinics at the Klinikum rechts der Isar der Technischen Universität München and at a private nephrological clinic in Weissenburg October 2007 to December 2008.
Criteria

Inclusion Criteria:

  • Age 18 or older
  • CKD 2-4

Exclusion Criteria:

  • pregnancy
  • history of malignant disease with a prognostic life expectancy less than 24 months
  • missing of written and informed consent
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01279460


Locations
Germany
Klinikum rechts der Isar
München, Bavaria, Germany, 81675
Klinikum Weissenburg
Weissenburg, Bavaria, Germany, 91781
Sponsors and Collaborators
Technische Universität München
Department of Nephrology, Klinikum rechts der Isar, München
Investigators
Principal Investigator: Marcus Baumann, M.D. PhD Klinikum rechts der Isar of the Technical University Munich
  More Information

Publications:
Responsible Party: PD. Dr. med. Marcus Baumann, M.D., PhD, Technical University of Munich, Klinikum rechts der Isar, Department of nephrology
ClinicalTrials.gov Identifier: NCT01279460     History of Changes
Other Study ID Numbers: Munich-CKD-PWA
First Submitted: January 17, 2011
First Posted: January 19, 2011
Last Update Posted: January 19, 2011
Last Verified: January 2011

Keywords provided by Technische Universität München:
chronic kidney disease
CKD
pulse wave velocity
PWV

Additional relevant MeSH terms:
Kidney Diseases
Renal Insufficiency, Chronic
Urologic Diseases
Renal Insufficiency