Aortic Stiffness in Chronic Kidney Disease Stage 2 to 4

This study has been completed.
Department of Nephrology, Klinikum rechts der Isar, München
Information provided by:
Technische Universität München Identifier:
First received: January 17, 2011
Last updated: NA
Last verified: January 2011
History: No changes posted
This study aimed to investigate in a cohort with chronic kidney disease the longitudinal relationship between aortic stiffness and renal function and mortality.

Decline in Renal Function

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Evaluation of Aortic Stiffness in CKD II to IV

Resource links provided by NLM:

Further study details as provided by Technische Universität München:

Primary Outcome Measures:
  • combined renal end-point (>25% decline in renal function or start of renal replacement therapy) [ Time Frame: 24 months ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • mortality [ Time Frame: 24 months ] [ Designated as safety issue: No ]

Enrollment: 167
Study Start Date: October 2007
Study Completion Date: December 2010
Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
CKD Cohort of patients with renal insufficiency
patients with renal insufficiency grade II-IV


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients were enrolled in a prospective study of vascular stiffness and CV risk in patients with CKD stages 2 to 4. They were predominantly recruited from outpatients attending nephrology clinics at the Klinikum rechts der Isar der Technischen Universität München and at a private nephrological clinic in Weissenburg October 2007 to December 2008.

Inclusion Criteria:

  • Age 18 or older
  • CKD 2-4

Exclusion Criteria:

  • pregnancy
  • history of malignant disease with a prognostic life expectancy less than 24 months
  • missing of written and informed consent
  Contacts and Locations
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Please refer to this study by its identifier: NCT01279460

Klinikum rechts der Isar
München, Bavaria, Germany, 81675
Klinikum Weissenburg
Weissenburg, Bavaria, Germany, 91781
Sponsors and Collaborators
Technische Universität München
Department of Nephrology, Klinikum rechts der Isar, München
Principal Investigator: Marcus Baumann, M.D. PhD Klinikum rechts der Isar of the Technical University Munich
  More Information

Responsible Party: PD. Dr. med. Marcus Baumann, M.D., PhD, Technical University of Munich, Klinikum rechts der Isar, Department of nephrology Identifier: NCT01279460     History of Changes
Other Study ID Numbers: Munich-CKD-PWA 
Study First Received: January 17, 2011
Last Updated: January 17, 2011
Health Authority: Ethikkommission der Fakultät für Medizin der Technischen Universität München, Germany:

Keywords provided by Technische Universität München:
chronic kidney disease
pulse wave velocity

Additional relevant MeSH terms:
Renal Insufficiency, Chronic
Kidney Diseases
Renal Insufficiency
Urologic Diseases processed this record on May 25, 2016