Correlation Between Wound Volume and Depth of Decubitus Ulcers And Resting Energy Expenditure
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|ClinicalTrials.gov Identifier: NCT01274650|
Recruitment Status : Completed
First Posted : January 11, 2011
Last Update Posted : October 13, 2016
|Condition or disease||Intervention/treatment||Phase|
|Decubitis Ulcer||Procedure: Indirect Calorimetry||Not Applicable|
Adequate nutrition is an important aspect of wound healing because it provides an anabolic environment necessary for tissue repair. Without proper nutrition support, healing can be prolonged and even inhibited. Provision of adequate energy is essential in patients with decubitus ulcers to maximize nitrogen retention and facilitate wound healing. (1,2) There are few published studies that measure energy needs in patients with decubitus ulcers. Spinal cord injured patients are one of the few populations where studies have utilized indirect calorimetry to measure energy expenditure. Individuals with spinal cord injuries are particularly at risk for developing pressure ulcers. Liu, et al. (3) measured energy expenditure in 16 individuals with quadriplegia and pressure ulcers and in 16 individuals with quadriplegia but no pressure ulcers. Measured energy expenditure was significantly higher in subjects with quadriplegia and pressure ulcers. Additionally, pressure ulcer surface area was significantly correlated with predicted resting energy expenditure. In a study of paraplegic individuals, Alexander, et al. (4) found resting metabolic rate was significantly higher in those individuals with pressure ulcers compared to those with paraplegia without pressure ulcers. Additional research is needed to confirm these findings.
To determine nutrition requirements specific to each patient, energy needs must be estimated, taking into account weight, height, age, activity level as well as the size of the wound and the patient's co-morbidities. Although indirect calorimetry is the gold standard for measuring metabolic rate, it is impractical and time consuming to use this method to determine needs of every patient. Therefore, the clinician uses predictive formulas for estimating energy needs. The most commonly cited guideline for energy requirements for healing pressure ulcers is 30-35 kcal/kg (recommendation, National Pressure Ulcer Advisory Panel).(1) The European Pressure Ulcer Advisory Panel has also recommended a minimum of 30-35 kcal/kg.(2) Several equations have been derived to predict metabolic rate based on age, height, weight, and sex. Two of these predictive equations are the Harris Benedict (5) and the Mifflin-St. Jeor. (6) These equations can be adjusted for injury factors, but it is unclear if they fully account for the size of wound in patients with decubiti.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||25 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Correlation Between Wound Volume and Depth of Decubitus Ulcers And Resting Energy Expenditure|
|Study Start Date :||September 2010|
|Actual Primary Completion Date :||September 2013|
|Actual Study Completion Date :||September 2014|
Patients admitted to the hospital with decubitus ulcers in the ischial, sacral, or coccyx area.
Procedure: Indirect Calorimetry
Other Name: Patients admitted to the hospital with decubitus ulcers in the ischial, sacral, or coccyx area
- Does the volume of decubitus ulcers have an effect on a patient's resting energy expenditure [ Time Frame: 1 year ]Data obtained in this study will be analyzed using methods that enable a description of the patient population and a comparison of the results against previously formulated equations for energy expenditure. Descriptive summaries will be presented for demographic and clinical background variables, study objectives, and outcome variables and safety endpoint
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01274650
|United States, Nebraska|
|Saint Elizabeth Regional Burn and Wound Center|
|Lincoln, Nebraska, United States, 68510|