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Impact of Genetic Polymorphisms on Dental Implant Loss (Polymorphism)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2015 by University Hospital, Ghent.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01274442
First Posted: January 11, 2011
Last Update Posted: June 3, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
University Hospital, Ghent
  Purpose

Patients that may participate in this case-control study underwent dental implant surgery in the University Hospital in Ghent in 2004-2007.

According to one of our recent papers based on this patient group, 34/461 patients lost one or more implants. The goal is to invite these 34 patients, to update the anamnesis, to perform a brief clinical oral examination and to have a blood sample. The latter is necessary to identify relevant genetic polymorphisms of the patient that are associated with implant loss. Among the remaining patients that did not lose implants, another 34 'controls' will be invited for the same examinations.


Condition Intervention
Patients Treated by Means of 1 or More Dental Implants Other: anamnesis Procedure: oral examination Procedure: Blood sample

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: A Case-control Study on the Impact of Genetic Polymorphisms on Dental Implant Loss.

Further study details as provided by University Hospital, Ghent:

Primary Outcome Measures:
  • genetic polymorphisms associated with implant loss [ Time Frame: after 3 to 6 years ]
    Identification of genetic polymorphisms that are associated with implant loss. It concerns only one evaluation (1 blood sample).


Estimated Enrollment: 68
Study Start Date: June 2011
Estimated Study Completion Date: December 2015
Estimated Primary Completion Date: December 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: CONTROL: no dental implants lost
Group of patients who received an implant during a dental implant surgery in the University Hospital in Ghent in 2004-2007, who did not lose their implants.
Other: anamnesis
To update the anamnesis.
Procedure: oral examination
A brief clinical oral examination will be performed.
Procedure: Blood sample
A blood sample will be taken to identify relevant genetic polymorphisms.
Experimental: CASE: patients lost one or more implants
Group of patients who received an implant during a dental implant surgery in the University Hospital in Ghent in 2004-2007, but who lost one or more implants.
Other: anamnesis
To update the anamnesis.
Procedure: oral examination
A brief clinical oral examination will be performed.
Procedure: Blood sample
A blood sample will be taken to identify relevant genetic polymorphisms.

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Dental implant surgery in the University Hospital in Ghent in 2004-2007.
  • Case: dental implant loss
  • Control: no dental implant loss

Exclusion Criteria:

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01274442


Contacts
Contact: Elisabeth De Wilde, Dentist Elisabeth.DeWilde@ugent.be

Locations
Belgium
University Hospital Ghent Recruiting
Ghent, Belgium, 9000
Contact: Elisabeth De Wilde, Dentist       Elisabeth.DeWilde@ugent.be   
Principal Investigator: Hugo De Bruyn, MD, PhD         
Sponsors and Collaborators
University Hospital, Ghent
Investigators
Principal Investigator: Hugo De Bruyn, MD, PhD University Hospital, Ghent
  More Information

Additional Information:
Responsible Party: University Hospital, Ghent
ClinicalTrials.gov Identifier: NCT01274442     History of Changes
Other Study ID Numbers: 2010/771
First Submitted: January 10, 2011
First Posted: January 11, 2011
Last Update Posted: June 3, 2015
Last Verified: June 2015

Keywords provided by University Hospital, Ghent:
dental implant