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Adiponectin and Circulating Progenitor Cells (CPC) Function

This study has been completed.
German Research Foundation
Heartcenter Leipzig GmbH
Information provided by (Responsible Party):
Prof. Dr. med. A. Linke, University of Leipzig Identifier:
First received: January 7, 2011
Last updated: June 1, 2015
Last verified: June 2015
Adiponectin and exercise training contribute to the maintenance of a normal vascular tone by influencing vascular NO bioavailability and concentration and function of endothelial progenitor cells. The molecular mechanisms are only partially understood. Therefore, aim of the present study is to elucidate the effects of Adiponectin on endothelial progenitor cell migration and the underlying signaling pathways. Furthermore, the impact of exercise training on adiponectin-mediated endothelial progenitor cell migration will be investigated.

Condition Intervention Phase
Coronary Artery Disease
Other: exercise training
Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Adiponectin Promotes the Migration of Circulating Progenitor Cells Through p38-mediated Induction of the CXCR4 Receptor

Resource links provided by NLM:

Further study details as provided by University of Leipzig:

Primary Outcome Measures:
  • migratory capacity of endothelial progenitor cells towards an SDF-1 gradient [ Time Frame: 4 weeks ]

Enrollment: 20
Study Start Date: January 2011
Study Completion Date: March 2011
Primary Completion Date: March 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: exercise training
4 weeks of supervised physical exercise training
Other: exercise training
4 weeks supervised physical exercise training
No Intervention: control
sedentary lifestyle
No Intervention: healthy control


Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • ≤ 75 years of age
  • stable coronary artery disease
  • preserved left ventricular function
  • physical work capacity of ≥ 50
  • successful elective percutaneous coronary intervention at study begin

Exclusion Criteria:

  • diabetes mellitus
  • hypercholesterolemia
  • untreated hypertension
  • smoking
  • myocardial infarction within the last 4 weeks
  • significant stenosis of the left main coronary artery
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Please refer to this study by its identifier: NCT01272674

University of Leipzig, Heart Center
Leipzig, Germany, 04289
Sponsors and Collaborators
University of Leipzig
German Research Foundation
Heartcenter Leipzig GmbH
Principal Investigator: Axel Linke, MD Heartcenter Leipzig GmbH
  More Information

Responsible Party: Prof. Dr. med. A. Linke, Co-investigator, University of Leipzig Identifier: NCT01272674     History of Changes
Other Study ID Numbers: adipo2008
Study First Received: January 7, 2011
Last Updated: June 1, 2015

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases processed this record on April 25, 2017