Cirrus HD-OCT Measurement of Area of Increased Light Penetration Under the Retinal Pigment Epithelium (RPE)
|ClinicalTrials.gov Identifier: NCT01272076|
Recruitment Status : Completed
First Posted : January 7, 2011
Results First Posted : November 14, 2013
Last Update Posted : January 20, 2014
|Condition or disease|
|Age Related Macular Degeneration Geographic Atrophy|
- To compare Cirrus HD-OCT automated measurements of the illumination area under the RPE to expert manual measurements of areas of hypofluorescence typical of geographic atrophy in fundus autofluorescence (FAF) images.
- To describe the differences and similarities between Cirrus HD-OCT and fundus autofluorescence images of subjects with geographic atrophy secondary to dry age-related macular degeneration (AMD).
- To determine the clinical factors that affect the Cirrus HD-OCT automated measurements of the illumination area under the RPE.
|Study Type :||Observational|
|Actual Enrollment :||85 participants|
|Official Title:||Cirrus HD-OCT Measurement of Area of Increased Light Penetration Under the Retinal Pigment Epithelium (RPE)|
|Study Start Date :||January 2011|
|Actual Primary Completion Date :||February 2011|
|Actual Study Completion Date :||February 2011|
Dry AMD and geographic atrophy
Patients diagnosed with dry AMD and geographic atrophy
- Difference in mm Squared of Cirrus HD-OCT Automated Measurements of the Illumination Areaa Under the RPE to Expert Manual Measurement of Areas of Hypofluorescence Typical of Geographic Atrophy (GA). [ Time Frame: August 2011 ]In retinal areas with atrophy, light emitted from the Cirrus penetrates the sclera and choroid which are more reflecting compared with the Retinal Pigment Epithelium (RPE). The areas with higher illumination are associated with areas of Geographic Atrophy (GA), and allow to quantify how big is the area of atrophy. The study will assess the difference between Cirrus HD-OCT measurements of areas of increased illumination under the RPE to hypofluorescence areas on fundus photos as assessed manually by retina specialists.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01272076
|United States, California|
|East Bay Retina Consultants, Inc.|
|Oakland, California, United States, 94609|
|United States, Michigan|
|TLC Eyecare and Laser Centers|
|Jackson, Michigan, United States, 49202|
|Principal Investigator:||Carmelina M Gordon, MD||TLC Eye Care and Laser Center|
|Principal Investigator:||Eugene S Lit, M.D.||East Bay Retina Consultants|