Incorporating Avocados in Meals
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|ClinicalTrials.gov Identifier: NCT01271829|
Recruitment Status : Completed
First Posted : January 7, 2011
Last Update Posted : March 18, 2014
The purpose of this study is to examine the effect of incorporating avocados in meals on post-ingestion glycemic index, insulin response, sensations of satiety and on appetite-related gastrointestinal peptide and hormone release. Also the effect of consuming avocado containing meals on the caloric intake of participants in subsequent eating episodes will be explored.
Each subject will participate in one intervention for one day, wait one or two weeks, come for another intervention, wait one or two weeks and come for a final intervention- three in total. Participants will be randomly assigned to one of six treatment sequences. Postprandial response to the control and two avocado-containing test meals will be assessed and compared using a 3 x 3 single blind cross-over design. The Subjects will be between 25 and 60 years old, female or male, with a BMI of 23 to 32, stable weight, no sports involvement, non-smoking and not dependent on caffeine. Thirty subjects will be recruited.
|Condition or disease||Intervention/treatment||Phase|
|Satiety Glycemic Index Insulin Gastrointestinal Peptides and Hormones||Dietary Supplement: Avocado supplement Dietary Supplement: Avocado included||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||30 participants|
|Intervention Model:||Crossover Assignment|
|Official Title:||Incorporating Avocados in Meals: Effect on Glycemic Index, Insulin Response, Satiety and Satiety-related Gastrointestinal Peptides in Humans|
|Study Start Date :||January 2011|
|Actual Primary Completion Date :||September 2012|
|Actual Study Completion Date :||September 2012|
No Intervention: Control
While on the control arm subjects will be given a meal with no avocado.
Active Comparator: Avocado supplement
While on the avocado supplement arm subjects will be given a meal in which a given amount of calories will be replaced by calories contributed by avocados.
Dietary Supplement: Avocado supplement
Calories from avocados replace calories of the control lunch
Active Comparator: Avocado included
While on the avocado included arm subjects will be given a meal in which the calories of avocado will be added to the calories of the control meal.
Dietary Supplement: Avocado included
Calories from avocados will be added to calories from the control lunch
- Satiety [ Time Frame: 12 hours ]The effect that consumption of avocados has on feelings of fullness and the quantity of food consumed in a subsequent eating episode
- post-ingestion glycemic index [ Time Frame: 3 hours ]Blood will be drawn at 30 minutes, 60 minutes, 120 minutes and 180 minutes after consumption of a meal with or without avocados. The glycemic index will be analyzed.
- insulin response [ Time Frame: 3 hours ]Blood will be drawn at 30 minutes, 60 minutes, 120 minutes and 180 minutes after consumption of a meal with or without avocados. Insulin response will be analyzed.
- appetite-related gastrointestinal peptide and hormone release [ Time Frame: 3 hours ]Blood will be drawn at 30 minutes, 60 minutes, 120 minutes and 180 minutes after consumption of a meal with or without avocados. Gastrointestinal peptide and hormones will be analyzed.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01271829
|United States, California|
|Loma Linda University, Department of Nutrition|
|Loma Linda, California, United States, 92350|
|Principal Investigator:||Joan Sabaté, MD, DrPH||Loma Linda University|