Screening for Coronary Artery Disease After Mediastinal Irradiation (SCAR)
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ClinicalTrials.gov Identifier: NCT01271127 |
Recruitment Status
:
Completed
First Posted
: January 6, 2011
Last Update Posted
: June 12, 2013
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Radiation Therapy Coronary Artery Disease Hodgkin Lymphoma | Radiation: CT coronary angiography | Not Applicable |
Objectives:
- to determine whether MSCT as a screening method of HL survivors treated with mediastinal irradiation accurately identifies asymptomatic significant coronary artery disease.
- to establish the prevelance of coronary abnormalities in HL survivors treated with mediastinal irradiation
- to determine the frequency and type of intervention
- to evaluate the acceptance of screening and asses quality of life among Hl survivors.
Study polulation:
50 long term survivors of HL, previously treatef with mediastinal irradiation without present evidence of cardiovascular disease
Intervention:
CT-coronary angiography and calcium score, to be performed as a screening method (to indicate further diagnostic treatent procedures)
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 50 participants |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Screening |
Official Title: | Screening for Coronary Artery Disease After Mediastinal Irradiation in Hodgkin Lymphoma Survivors |
Study Start Date : | January 2011 |
Actual Primary Completion Date : | June 2013 |
Actual Study Completion Date : | June 2013 |
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Radiation: CT coronary angiography
- accurately identifying asymptomatic coronary artery disease [ Time Frame: one year ]to determine whether Ct coronary angiography as a screening method acuurately identifies asymptomatic coronary artery disease in a high risk poulation (HL survivors after mediastinal irradiation)
- prevalnce of cornary artery disease and frequency/type of subsequent intervention [ Time Frame: one year ]to establish the prevelence of coronary abnormalities in HL survivors treated with mediastinal irradiation, and to determine the frequency and type of subsequent interventions

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Ages Eligible for Study: | 35 Years to 60 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- history of Hodgkin Lymphoma(all stages) with at least 10 disease free survival
- current age between 35-60
- mediastinal irradiation as part of HL treatment, radiotherapy data available
- written informed consent
Exclusion Criteria:
- current treatment for cardiovascualr disease, excelt hypertension hypercholesterolemia or cardiac murmurs
- known or sypmtomatic heart failure
- impaired kidney function (Cockcroft < 55 ml/min)
- known contrast allergy
- invasive angiography in past 2 years
- presence of life threatening disorder

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01271127
Netherlands | |
Leiden University Medical Center | |
Leiden, Zuid-Holland, Netherlands, 2300WB |
Principal Investigator: | A.D.G. KRol, MD, PhD | Leiden University Medical Centre |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | L.A.Daniels, MD, Leiden University Medical Center |
ClinicalTrials.gov Identifier: | NCT01271127 History of Changes |
Other Study ID Numbers: |
NL31278.058.10 |
First Posted: | January 6, 2011 Key Record Dates |
Last Update Posted: | June 12, 2013 |
Last Verified: | June 2013 |
Keywords provided by L.A.Daniels, Leiden University Medical Center:
radiation therapy coronary artery disease Hodgkin Lymphoma |
Additional relevant MeSH terms:
Lymphoma Coronary Artery Disease Myocardial Ischemia Coronary Disease Hodgkin Disease Neoplasms by Histologic Type Neoplasms Lymphoproliferative Disorders |
Lymphatic Diseases Immunoproliferative Disorders Immune System Diseases Heart Diseases Cardiovascular Diseases Arteriosclerosis Arterial Occlusive Diseases Vascular Diseases |