Entecavir for Chronic Hepatitis B in Hepatocellular Carcinoma Patients Underwent Radiofrequency Ablation Therapy
|ClinicalTrials.gov Identifier: NCT01270178|
Recruitment Status : Unknown
Verified January 2011 by Taipei Veterans General Hospital, Taiwan.
Recruitment status was: Not yet recruiting
First Posted : January 5, 2011
Last Update Posted : January 5, 2011
Persistent replication of HBV (47-55%) is frequently found in patients with HCC, which in turn leads to deterioration of liver reserve. Moreover, a large proportion of HCC patients who underwent curative therapy died from progressive liver decompensation rather than recurrence of cancer. It had been proved that anti-viral therapy for hepatitis C virus (HCV)-related HCC patients could reduce the rate of tumor recurrence after surgical resection.
This is a prospective study to evaluate the efficacy of ETV therapy in chronic hepatitis B patients after receiving RFA therapy for HCC.
|Condition or disease||Intervention/treatment|
|Chronic Hepatitis B Hepatocellular Carcinoma||Drug: Entecavir|
|Study Type :||Observational|
|Estimated Enrollment :||420 participants|
|Official Title:||Prospective Trial of Entecavir for Chronic Hepatitis B in Hepatocellular Carcinoma Patients Underwent Radiofrequency Ablation Therapy|
|Study Start Date :||January 2011|
film coated tablets / 0.5mg / once daily / 3 years
- The survival rate and recurrence rate between patients receiving ETV therapy and those in historical control [ Time Frame: 3 years ]
- HBV reactivation, incidence of ALT normalization, reduction of serum HBV DNA level, HBsAg loss and HBsAg seroconversion to anti-HBsAb, emergence of resistance. [ Time Frame: 3 years ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01270178
|Contact: Chien-Wei Su, M.D.||02-28712121 ext firstname.lastname@example.org|
|Department of Medicine, Taipei Veterans General Hospital||Not yet recruiting|
|Contact: Chien-Wei Su, M.D. 02-28712121 ext 2049 email@example.com|
|Principal Investigator: Jaw-Ching Wu, M.D. Ph.D.|