Entecavir for Chronic Hepatitis B in Hepatocellular Carcinoma Patients Underwent Radiofrequency Ablation Therapy
Recruitment status was: Not yet recruiting
Persistent replication of HBV (47-55%) is frequently found in patients with HCC, which in turn leads to deterioration of liver reserve. Moreover, a large proportion of HCC patients who underwent curative therapy died from progressive liver decompensation rather than recurrence of cancer. It had been proved that anti-viral therapy for hepatitis C virus (HCV)-related HCC patients could reduce the rate of tumor recurrence after surgical resection.
This is a prospective study to evaluate the efficacy of ETV therapy in chronic hepatitis B patients after receiving RFA therapy for HCC.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Prospective Trial of Entecavir for Chronic Hepatitis B in Hepatocellular Carcinoma Patients Underwent Radiofrequency Ablation Therapy|
- The survival rate and recurrence rate between patients receiving ETV therapy and those in historical control [ Time Frame: 3 years ] [ Designated as safety issue: Yes ]
- HBV reactivation, incidence of ALT normalization, reduction of serum HBV DNA level, HBsAg loss and HBsAg seroconversion to anti-HBsAb, emergence of resistance. [ Time Frame: 3 years ] [ Designated as safety issue: Yes ]
|Study Start Date:||January 2011|
film coated tablets / 0.5mg / once daily / 3 years
Please refer to this study by its ClinicalTrials.gov identifier: NCT01270178
|Department of Medicine, Taipei Veterans General Hospital|