Improving Methadone Maintenance Treatment Compliance and Outcomes in China

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01270113
Recruitment Status : Completed
First Posted : January 5, 2011
Last Update Posted : January 5, 2011
National Institute on Drug Abuse (NIDA)
Information provided by:
University of California, Los Angeles

Brief Summary:
China faces the challenge of dual epidemics of drug use and HIV/AIDS. In responding to concerns of high rates of HIV/AIDS and other medical consequences among heroin users, China has recently implemented methadone maintenance treatment (MMT) programs nationwide. One problem noted with this rapid expansion is that the dropout rates from MMT have been high. The proposed study will adapt a motivational incentives (MI) intervention developed in the United States for use in Chinese MMT settings and will pilot test its effectiveness in improving treatment compliance and outcomes. The study's primary aims are: 1. to adapt a motivational incentives intervention in MMT in China, and 2. to experimentally pilot test the motivational incentives intervention. A secondary aim is to explore factors that may influence the outcomes of MMT that incorporates a motivational incentives intervention. It is hypothesized that the MI intervention can be adapted to Chinese settings and that it will optimize the positive outcomes of MMT in reducing HIV risks among heroin abusers. The collaborative team includes researchers in American and Chinese institutes (UCLA/Johns Hopkins/Washington, Shanghai Mental Health Center, Yunnan Institute for Drug Abuse), officials from national and local Chinese Centers for Disease Control and Prevention, and providers in local MMT clinics in Shanghai and Yunnan.

Condition or disease Intervention/treatment Phase
Methadone Behavioral: contingency management Not Applicable

Study Type : Interventional  (Clinical Trial)
Official Title: Improving Methadone Maintenance Treatment Compliance and Outcomes in China

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All

Inclusion Criteria:adult patients entering the participating MMT clinics during the recruitment period who are dependent on heroin and who are willing to participate in the study.

Exclusion Criteria:Patients who are diagnosed with severe mental illness will not be eligible to participate.

Responsible Party: Yih-Ing Hser, Ph.D., Professor, Principal Investigator, UCLA Integrated Substance Abuse Programs Identifier: NCT01270113     History of Changes
Other Study ID Numbers: DESPR DA025252
5R21DA025252-02 ( U.S. NIH Grant/Contract )
First Posted: January 5, 2011    Key Record Dates
Last Update Posted: January 5, 2011
Last Verified: December 2010

Additional relevant MeSH terms:
Analgesics, Opioid
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Antitussive Agents
Respiratory System Agents