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Improving Methadone Maintenance Treatment Compliance and Outcomes in China

This study has been completed.
ClinicalTrials.gov Identifier:
First Posted: January 5, 2011
Last Update Posted: January 5, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
National Institute on Drug Abuse (NIDA)
Information provided by:
University of California, Los Angeles
China faces the challenge of dual epidemics of drug use and HIV/AIDS. In responding to concerns of high rates of HIV/AIDS and other medical consequences among heroin users, China has recently implemented methadone maintenance treatment (MMT) programs nationwide. One problem noted with this rapid expansion is that the dropout rates from MMT have been high. The proposed study will adapt a motivational incentives (MI) intervention developed in the United States for use in Chinese MMT settings and will pilot test its effectiveness in improving treatment compliance and outcomes. The study's primary aims are: 1. to adapt a motivational incentives intervention in MMT in China, and 2. to experimentally pilot test the motivational incentives intervention. A secondary aim is to explore factors that may influence the outcomes of MMT that incorporates a motivational incentives intervention. It is hypothesized that the MI intervention can be adapted to Chinese settings and that it will optimize the positive outcomes of MMT in reducing HIV risks among heroin abusers. The collaborative team includes researchers in American and Chinese institutes (UCLA/Johns Hopkins/Washington, Shanghai Mental Health Center, Yunnan Institute for Drug Abuse), officials from national and local Chinese Centers for Disease Control and Prevention, and providers in local MMT clinics in Shanghai and Yunnan.

Condition Intervention
Methadone Behavioral: contingency management

Study Type: Interventional
Official Title: Improving Methadone Maintenance Treatment Compliance and Outcomes in China

Resource links provided by NLM:

Further study details as provided by University of California, Los Angeles:


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All

Inclusion Criteria:adult patients entering the participating MMT clinics during the recruitment period who are dependent on heroin and who are willing to participate in the study.

Exclusion Criteria:Patients who are diagnosed with severe mental illness will not be eligible to participate.

  Contacts and Locations
No Contacts or Locations Provided
  More Information

Responsible Party: Yih-Ing Hser, Ph.D., Professor, Principal Investigator, UCLA Integrated Substance Abuse Programs
ClinicalTrials.gov Identifier: NCT01270113     History of Changes
Other Study ID Numbers: DESPR DA025252
5R21DA025252-02 ( U.S. NIH Grant/Contract )
First Submitted: January 4, 2011
First Posted: January 5, 2011
Last Update Posted: January 5, 2011
Last Verified: December 2010

Additional relevant MeSH terms:
Analgesics, Opioid
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Antitussive Agents
Respiratory System Agents