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The Effect of Volatile Anesthetics Sevoflurane and Desflurane on Liver, Renal and Cardiovascular Systems During Liver Surgery

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified December 2010 by Aretaieio Hospital.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01267786
First Posted: December 29, 2010
Last Update Posted: December 29, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Aretaieio Hospital
  Purpose
The aim of the study is to investigate the effect of sevoflurane and desflurane on hepatic function after ischemic/reperfusion injury and the sequence influence on renal and cardiovascular systems.

Condition Intervention Phase
Apoptosis Liver Surgery Procedure: Liver surgery Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: The Effect of Volatile Anesthetics Sevoflurane and Desflurane on Liver, Renal and Cardiovascular Systems During Liver Surgery

Resource links provided by NLM:


Further study details as provided by Aretaieio Hospital:

Primary Outcome Measures:
  • Oxidotic stress after hepatectomy. [ Time Frame: 5 d postop. ]
    Perioperative liver and renal biopsies and follow up with liver renal function tests plus intraoperative and postoperative cardiovascular monitoring


Secondary Outcome Measures:
  • Liver and renal dysfunction [ Time Frame: 5 d ]
    liver and renal impairment due to ischemic injury


Estimated Enrollment: 40
Study Start Date: December 2010
Estimated Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Sevoflurane
1MAC intraoperatively
Procedure: Liver surgery
hepatectomy
Active Comparator: desflurane
1 MAC intraoperatively
Procedure: Liver surgery
hepatectomy

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   30 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients undergoing liver surgery

Exclusion Criteria:

  • ASA IV, Cardiovascular diseases
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01267786


Contacts
Contact: Georgios P Fragulidis, MD +30 6072910955 gfragulidis@aretaieio.uoa.gr
Contact: Aikaterini D Melemeni, MD, DESA +30 6946194817 amelemeni@med.uoa.gr

Locations
Greece
Aretaieio Hospital Recruiting
Athens, Attica, Greece, 115 28
Principal Investigator: Georgios P Fragulidis, MD         
Sponsors and Collaborators
Aretaieio Hospital
Investigators
Principal Investigator: Georgios P Fragulidis, MD Areataieio Hospital
  More Information

Responsible Party: G.P. Fragulidis MD, Ass. Prof. Surgery, University of Athens
ClinicalTrials.gov Identifier: NCT01267786     History of Changes
Other Study ID Numbers: AnesthSurg1
First Submitted: December 28, 2010
First Posted: December 29, 2010
Last Update Posted: December 29, 2010
Last Verified: December 2010

Keywords provided by Aretaieio Hospital:
Oxidotic stress

Additional relevant MeSH terms:
Anesthetics
Sevoflurane
Desflurane
Central Nervous System Depressants
Physiological Effects of Drugs
Platelet Aggregation Inhibitors
Anesthetics, Inhalation
Anesthetics, General