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The Effect of Volatile Anesthetics Sevoflurane and Desflurane on Liver, Renal and Cardiovascular Systems During Liver Surgery

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified December 2010 by Aretaieio Hospital.
Recruitment status was:  Recruiting
Information provided by:
Aretaieio Hospital Identifier:
First received: December 28, 2010
Last updated: NA
Last verified: December 2010
History: No changes posted
The aim of the study is to investigate the effect of sevoflurane and desflurane on hepatic function after ischemic/reperfusion injury and the sequence influence on renal and cardiovascular systems.

Condition Intervention Phase
Liver Surgery
Procedure: Liver surgery
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: The Effect of Volatile Anesthetics Sevoflurane and Desflurane on Liver, Renal and Cardiovascular Systems During Liver Surgery

Resource links provided by NLM:

Further study details as provided by Aretaieio Hospital:

Primary Outcome Measures:
  • Oxidotic stress after hepatectomy. [ Time Frame: 5 d postop. ]
    Perioperative liver and renal biopsies and follow up with liver renal function tests plus intraoperative and postoperative cardiovascular monitoring

Secondary Outcome Measures:
  • Liver and renal dysfunction [ Time Frame: 5 d ]
    liver and renal impairment due to ischemic injury

Estimated Enrollment: 40
Study Start Date: December 2010
Estimated Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Sevoflurane
1MAC intraoperatively
Procedure: Liver surgery
Active Comparator: desflurane
1 MAC intraoperatively
Procedure: Liver surgery


Ages Eligible for Study:   30 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients undergoing liver surgery

Exclusion Criteria:

  • ASA IV, Cardiovascular diseases
  Contacts and Locations
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Please refer to this study by its identifier: NCT01267786

Contact: Georgios P Fragulidis, MD +30 6072910955
Contact: Aikaterini D Melemeni, MD, DESA +30 6946194817

Aretaieio Hospital Recruiting
Athens, Attica, Greece, 115 28
Principal Investigator: Georgios P Fragulidis, MD         
Sponsors and Collaborators
Aretaieio Hospital
Principal Investigator: Georgios P Fragulidis, MD Areataieio Hospital
  More Information

Responsible Party: G.P. Fragulidis MD, Ass. Prof. Surgery, University of Athens Identifier: NCT01267786     History of Changes
Other Study ID Numbers: AnesthSurg1
Study First Received: December 28, 2010
Last Updated: December 28, 2010

Keywords provided by Aretaieio Hospital:
Oxidotic stress

Additional relevant MeSH terms:
Central Nervous System Depressants
Physiological Effects of Drugs
Platelet Aggregation Inhibitors
Anesthetics, Inhalation
Anesthetics, General processed this record on April 26, 2017