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Clinical and Biochemical Effects of Multipass Hemodialysis (MHD)

This study has been completed.
Flexdialysis ApS
Information provided by (Responsible Party):
James heaf, Herlev Hospital Identifier:
First received: January 26, 2010
Last updated: July 6, 2013
Last verified: July 2013
The purpose of this study is to investigate whether recycled dialysis fluid can supply enough clearance for hemodiaysis patients.

Condition Intervention Phase
Uremia Device: Multipass hemodialysis Phase 2

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Clinical and Biochemical Effects of Multipass Hemodialysis

Resource links provided by NLM:

Further study details as provided by James heaf, Herlev Hospital:

Primary Outcome Measures:
  • Urea Kt/V [ Time Frame: 9 hours ]

Secondary Outcome Measures:
  • Creatinine clearance [ Time Frame: 9 hours ]
  • Patient symptoms [ Time Frame: 9 hours ]

Enrollment: 12
Study Start Date: March 2011
Study Completion Date: June 2011
Primary Completion Date: June 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: conventional HD
conventional 4-hour HD
Device: Multipass hemodialysis
8-hour dialysis using a recycled dialysis bath of 25-30 l
Other Names:
  • dialysis
  • hemodialysis
  • dialysate

Detailed Description:

Conventional hemodialysis uses large amounts of water, which hinders travel possibilies for home hemodialysis (HD) patients. We have developed a recycling system using 25-30 l dialysate per dialysis. In vitro investigations show that this results in adequate dialysis.

12 HD patients will be studied during two dialysis sessions. The first HD will be a conventional 4 hour dialysis, using single pass dialysate. The second will be an 8-hour HD using multipass (recycled) dialysate 25-30 l. Clearance of urea, creatinine, phosphate and cobalamin will be measured both in the patient and the dialysate. Patient symptoms will be recorded.


Ages Eligible for Study:   18 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Stable chronic HD patients
  • Informed consent

Exclusion Criteria:

  • Age <18 years
  • Psychiatric disease
  Contacts and Locations
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Please refer to this study by its identifier: NCT01267760

Herlev Hospital
Herlev, Denmark, 2880
Sponsors and Collaborators
Herlev Hospital
Flexdialysis ApS
Principal Investigator: James G Heaf, MD DMSc Herlev Hospital
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: James heaf, chief physician, Herlev Hospital Identifier: NCT01267760     History of Changes
Other Study ID Numbers: mhd1
Study First Received: January 26, 2010
Last Updated: July 6, 2013

Keywords provided by James heaf, Herlev Hospital:
Effect of recycled low-volume dialysate on dialysis efficacy

Additional relevant MeSH terms:
Dialysis Solutions
Pharmaceutical Solutions processed this record on September 21, 2017