Macrophage Migration Inhibitory Factor (MIF)- Cardiac Surgery
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|ClinicalTrials.gov Identifier: NCT01267721|
Recruitment Status : Completed
First Posted : December 28, 2010
Last Update Posted : October 8, 2014
|Condition or disease||Intervention/treatment|
|Heart Surgery||Procedure: Blood sampling|
The trace element selenium (Se) serves as an essential co-factor for the antioxidant enzymes Thioredoxin - reductase (TRR) and many other antioxidant enzymes, which protect tissues from oxidative stress. In septic patients it has previously been shown that thioredoxin, a TRR regulated Redox Enzyme, has the ability to suppress the synthesis of MIF.
Aim of the present study is therefore to investigate the relation between perioperative selenium decrease and the reduction of TRR activity with a possible release of MIF during the inflammatory response after cardiac surgery.
|Study Type :||Observational|
|Actual Enrollment :||100 participants|
|Official Title:||Macrophage Migration Inhibitory Factor (MIF) as a Marker of Perioperative Inflammatory Reaction During Heart Surgery|
|Study Start Date :||January 2011|
|Actual Primary Completion Date :||December 2012|
A single group of 100 consecutive patients will undergo additional blood sampling at different time points
Procedure: Blood sampling
Blood sampling at various time points. Additional 92 mL blood.
- Pilot study: correlation between clinical and lab parameters [ Time Frame: two months ]
To assess the importance of the MIF ligand/receptor family in a large cohort of patients (n=100) undergoing cardiac surgery and to characterize the underlying molecular events.
Possible correlation between several clinical and laboratory parameters will be analyzed. This is a pilot study to generate hints at future items to be studied in controlled trials.
- Secondary Outcome [ Time Frame: two months ]
- Correlation between perioperative MIF and MIF-2 levels and postoperative outcome
- Measurement of sCD74/MIF complex
- Determination of MIF polymorphism and its significance on clinical outcome
- perioperative inflammation
- organ injury
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01267721
|RWTH Aachen University Hospital|
|Aachen, NRW, Germany, 52074|
|Principal Investigator:||Steffen Rex, PD Dr. med.||RWTH Aachen University Hospital|