Methods for Objective Selection of Competent Sperm (MACS)
In spite of the achievements and developement of the assisted reproduction techniques in the last years, there is still an elevated percentage of unsuccessful treatments, needing sometimes repeated attempts to reach pregnancy.
The molecular physiology of sperm is being better characterized, and some reports have demonstrated the implication of different molecular processes in the pathophysiology of male infertility.
Recently, different sperm selection methods have been based on these molecular differences, showing a better quality of the sperm population after selection.
The main objective of this research project is to clinically apply these techniques in order to increase the pregnancy rates per cycle in infertile couples attending assisted reproduction treatments.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Outcomes Assessor)
Primary Purpose: Treatment
- Gestation [ Time Frame: 14 days ] [ Designated as safety issue: No ]Sperm selection and blood sample confirming gestation
|Study Start Date:||October 2010|
|Study Completion Date:||December 2012|
|Primary Completion Date:||December 2012 (Final data collection date for primary outcome measure)|
No Intervention: Control
No sperm selection
Experimental: Annexine V negative
Sperm selection with Annexine V protein
Other: Negative selection
Sperm selection to continue the treatment with healthy sperm
Please refer to this study by its ClinicalTrials.gov identifier: NCT01265329
|Valencia, Spain, 46015|
|Principal Investigator:||Nicolas Garrido, PhD||IVI Valencia|