Non-cancer Pain and Cognitive Impairment: A Disabling Relationship
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ClinicalTrials.gov Identifier: NCT01264965
Recruitment Status :
To compare the efficacy of long-acting oxycodone to extended-release acetaminophen in older persons with no and mild to moderate cognitive impairment and persistent moderate or higher intensity non-cancer lower extremity arthritis pain; and Describe the association of change in non-cancer pain self-report with an older adults functional status (BPI and WOMAC and brief physical performance measure) and to determine if cognitive status modifies this relationship.
Condition or disease
Drug: long acting oxycodoneDrug: extra strength acetaminophen
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Ages Eligible for Study:
65 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
age over 65
Pain at least 3 months duration
Pain greater in lower extremity than other anatomical site with ambulation
Pain self-report of moderate intensity of higher on an average day
Physician states participants have decision-making capacity to enroll into the trial
Participants with cognitive impairment have a reliable caregiver
Inadequate pain relief from NSAIDS and/or acetaminophen in the past
Current cancer requiring chemotherapy
History of addiction to opioids or other controlled substance
Consumes more than 2 alcoholic drinks a day
Severe balance disturbance
Intra-articular steroid injection in the past 6 weeks