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Cardiometabolic Risk of Shiftwork (SW)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2013 by University of Chicago.
Recruitment status was  Recruiting
Information provided by (Responsible Party):
University of Chicago Identifier:
First received: December 13, 2010
Last updated: September 4, 2013
Last verified: January 2013
The overall goal of the present application is to test the hypothesis that shift workers, who are chronically exposed to circadian misalignment and sleep loss, have a higher cardio-metabolic risk than day workers, and that the accumulated sleep debt and the degree of circadian misalignment both predict their elevated cardio-metabolic risk.

Sleep Deprivation
Circadian Dysregulation
Shift-Work Sleep Disorder

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Cardiometabolic Risk of ShiftWork: Sleep Loss vs.Circadian Disruption

Further study details as provided by University of Chicago:

Estimated Enrollment: 90
Study Start Date: August 2009
Estimated Primary Completion Date: June 2014 (Final data collection date for primary outcome measure)
Shift Workers
Day Workers


Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
We will enroll 44-46 regular day workers (work hours between 7:00 a.m. and 7:00 p.m. on all work days) and 44-46 shift workers on rotating schedules (changing shift at lease once a week and having work hours between 7:00 p.m. and 7:00 a.m. on at least 10 days per month). Both groups of subjects will work at least 30 hours per week at the University of Chicago, University of Chicago Medical Center, or other Chicago area medical center and have maintained their work schedule for at least 6 months.

Inclusion Criteria:

  • Day workers and shift workers at the University of Chicago, University of Chicago Medical Center, or another Chicago area medical center who have maintained their work schedule (at least 30 hours/week) for at least 6 months.
  • Individuals who have been shift workers for less than 10 years; body mass index <40 kg/m2;
  • No major illness
  • No history of psychiatric, endocrine, cardiac or sleep disorders
  • Those with hypertension or dyslipidemia will be included if these conditions are controlled by a stable treatment.
  • Women taking oral contraceptive or hormonal replacement therapy will be included only if they plan to stay on a stable regimen throughout the study.
  • Age must be between 18 and 50 years

Exclusion Criteria:

  • Individuals who have worked at the University of Chicago, University of Chicago Medical Center, or another Chicago area medical center in their current position for less than 6 months.
  • Individuals who have been shift workers for more than 10 years
  • BMI>40 kg/m2
  • Individuals with a major illness (e.g. diabetes, sleep disorder)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01264913

Contact: Lauran DeCeault 773-834-3144

United States, Illinois
The University of Chicago Recruiting
Chicago, Illinois, United States, 60637
Contact: Eve Van Cauter, PhD         
Principal Investigator: Eve Van Cauter, PhD         
Sponsors and Collaborators
University of Chicago
Principal Investigator: Eve Van Cauter University of Chicago
  More Information

Responsible Party: University of Chicago Identifier: NCT01264913     History of Changes
Other Study ID Numbers: 09-049-A 
Study First Received: December 13, 2010
Last Updated: September 4, 2013
Health Authority: United States: Food and Drug Administration

Additional relevant MeSH terms:
Sleep Disorders, Circadian Rhythm
Sleep Wake Disorders
Sleep Deprivation
Chronobiology Disorders
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Mental Disorders
Occupational Diseases processed this record on September 23, 2016