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Microvesicle Production After Acute Trauma and Its Clinical Impact on Venothromboembolism

This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
Myung S. Park, Mayo Clinic Identifier:
First received: December 20, 2010
Last updated: April 27, 2016
Last verified: April 2016
The purpose of this research study is to look at how trauma affects the ability of blood to clot. The blood of people who suffer a traumatic injury can under-clot or over-clot, and this research study will look at blood drawn from people after they suffer a traumatic injury to see how well their blood clots.


Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Microvesicle Production After Acute Trauma and Its Clinical Impact on Venothromboembolism

Resource links provided by NLM:

Further study details as provided by Mayo Clinic:

Primary Outcome Measures:
  • Estimate the distribution over time of procoagulant Microvesicles (MVs) concentration by cell of origin and endogenous thrombin potential (ETP). [ Time Frame: 6 months ]
  • Determine the cumulative incidence of Venothromboembolism (VTE) within three months after major trauma and test the distribution of procoagulant MV concentration and endogenous thrombin generation potential over time as potential predictors of VTE. [ Time Frame: 4 years ]

Estimated Enrollment: 2720
Study Start Date: January 2011
Estimated Primary Completion Date: January 2017 (Final data collection date for primary outcome measure)
Traumatic Injury
Trauma patients arriving at Saint Mary's Emergency Department
Control group


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Trauma patients arriving to Saint Mary's Emergency Department and control patients.

Inclusion Criteria:

  • Male and female patients 18 years of age or older
  • Blunt trauma patients including those with closed head injury
  • Penetrating trauma patients

Exclusion Criteria:

  • Are on therapeutic anticoagulation
  • Have preexisting coagulopathy
  • Patients greater than 12 hours from time of injury
  • Have history of malignancy or preexisting diagnosis of sepsis or renal failure
  • Patients with burn injuries
  • Male and female patients younger than 18 years of age
  • Pregnant patients
  Contacts and Locations
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Please refer to this study by its identifier: NCT01264458

United States, Minnesota
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Sponsors and Collaborators
Mayo Clinic
Principal Investigator: Myung Park, M.D. Mayo Clinic
  More Information

Responsible Party: Myung S. Park, Assistant Professor of Surgery, Mayo Clinic Identifier: NCT01264458     History of Changes
Other Study ID Numbers: 10-001889
Study First Received: December 20, 2010
Last Updated: April 27, 2016 processed this record on April 26, 2017