Study of the Fixation of Various Vectors in PET/CT in Patients With a With Lung Cancer Before and During of CRT or RT (RTEP4)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01261585
Recruitment Status : Completed
First Posted : December 16, 2010
Last Update Posted : December 16, 2010
Information provided by:
Centre Henri Becquerel

Brief Summary:

Study of the modification of the fixation(binding) of Fluoro-2-deoxy-D-glucose (FDG), fluoro-misonidazole (FMISO) and 3'deoxy-3-fluoro-thymidine deoxy-3-fluoro-thymidine (FLT) measured in tomography by broadcast(emission,issue) of positrons (PET) at patients before and in the course of exclusive radiotherapy or concomitant radiochemotherapy for primitive bronchial cancer.

This protocle allows to study the simultaneous variations of the metabolism, the hypoxie and the cellular proliferation by PET SCAN at 5 patients reached(affected) by a primitive bronchial cancer in the course of exclusive radiotherapy for primitive bronchial cancer not small cell lung.

The investigators are also going to study several scenarii of optimization of the radiotherapy according to the variations of the tumoral metabolism, the hypoxie and the cellular proliferation measured in the course of radiotherapy (theoretical study on console using the scanner and the various examinations).

Condition or disease
Bronchial Neoplasms Carcinoma, Non-Small-Cell Lung

Study Type : Observational
Actual Enrollment : 5 participants
Time Perspective: Prospective
Official Title: Study of the Modification of the Fixation of FDG, F-Miso and FLT Measured in PET/CT at Patients Before and in the Course of Exclusive Radiotherapy or Concomitant Radiochemotherapy for Primitive Bronchial Cancer
Study Start Date : December 2008
Actual Primary Completion Date : November 2009
Actual Study Completion Date : December 2009

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Diagnosed patients with non-small-cell lung carcinoma

Inclusion Criteria:

  • patients with non-small-cell lung carcinoma hitologicaly proved
  • Candidate patients in a treatment with aim guardian by exclusive thoracic radiotherapy or of concomitant radiochemotherapy (tumoral dose superior to 60 Gy) ( n=5 ).
  • Measurable tumor according to the criteria of evaluation RECIST

Exclusion Criteria:

  • Histology other one than primitive bronchial cancer not in small cells lung
  • The patients for whom no tumoral target is assessable (forgiveness completes after first chemotherapy, operated patients).
  • Patients for whom a radiotherapy with curative aim is not indicated (tumoral extension, metastases, general state, co-morbidity).
  • Patient having benefited from an examination PET in the FDG with in more than 4 weeks and for which a new PET in the FDG is not necessary with in the framework of its disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01261585

Centre Henri Becquerel
Rouen, Hate Normandie, France, 76000
Sponsors and Collaborators
Centre Henri Becquerel
Principal Investigator: GUERNOU Mohamed, MD CHBecquerel
Study Director: VERA Pierre, MD phD CHBecquerel

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Mohamed GUERNOU MD, Centre Henri Becquerel Identifier: NCT01261585     History of Changes
Other Study ID Numbers: CHB 08-01
First Posted: December 16, 2010    Key Record Dates
Last Update Posted: December 16, 2010
Last Verified: January 2009

Keywords provided by Centre Henri Becquerel:
Positron-Emission Tomography
PET Scan
Non-Small-Cell Lung Carcinoma
chemo-Radiation Oncology

Additional relevant MeSH terms:
Carcinoma, Non-Small-Cell Lung
Bronchial Neoplasms
Carcinoma, Bronchogenic
Lung Neoplasms
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Lung Diseases
Respiratory Tract Diseases
Bronchial Diseases