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Effect of Heparin on Femoral Arterial Sheaths Thrombosis During Diagnostic Coronary Angiography

This study has been completed.
Information provided by:
Prince Sultan Cardiac Center, Adult Cardiology Department. Identifier:
First received: November 19, 2010
Last updated: December 14, 2010
Last verified: December 2010
The project tests the incidence of femoral arterial sheath thrombus formation during diagnostic coronary angiography and effect of intravenous (iv) heparin bolus administration in reducing this risk in comparison to placebo.

Condition Intervention Phase
Diagnostic Coronary Angiography Drug: Heparin Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
Official Title: Efficacy of a Single Dose Intravenous Heparin During Diagnostic Angiography in Reducing Sheath-clot Formation: A Randomized Controlled Trial

Resource links provided by NLM:

Further study details as provided by Prince Sultan Cardiac Center, Adult Cardiology Department.:

Primary Outcome Measures:
  • The incidence of femoral arterial sheath thrombi and the efficacy of heparin bolus in preventing sheath thrombosis

Enrollment: 304
Study Start Date: July 2008
Study Completion Date: October 2010
Primary Completion Date: October 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: active arm: heparin Drug: Heparin
unfractionated heparin 2000 unites
Other Name: unfractionated heparin

  Show Detailed Description


Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Included all adult patients undergoing cardiac catheterization

Exclusion Criteria:

  • Contraindication to heparin
  • Platelet count <100,000/mm3
  • Patient with bleeding diathesis or hypercoagulable state.
  • Use of chronic anticoagulation with INR > 1.4
  • Patient refusal or inability to follow the protocol
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01260519

Saudi Arabia
Prince Sultan Cardiac Center
Riyadh, Central, Saudi Arabia, 11159
Sponsors and Collaborators
Prince Sultan Cardiac Center, Adult Cardiology Department.
Principal Investigator: Abdulrahman M Almoghairi, MD Prince Sultan Cardiac Centre (PSCC)
  More Information

Responsible Party: Abdulrahman M Al-Moghairi,MD,MRCP, SFC, Prince Sultan Cardiac Center, Adult Cardiology Department. Identifier: NCT01260519     History of Changes
Other Study ID Numbers: PSCC-00001- HT
Study First Received: November 19, 2010
Last Updated: December 14, 2010

Additional relevant MeSH terms:
Calcium heparin
Fibrinolytic Agents
Fibrin Modulating Agents
Molecular Mechanisms of Pharmacological Action processed this record on July 26, 2017