Effects of Expiratory Pressure on Arterial Oxygenation During Hypoxia (hypex)
Recruitment status was: Recruiting
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Arterial Oxygenation During Hypoxia : Effects of an Added Expiratory Resistance|
- SpO2 [ Time Frame: mean over 1 minute ]after three minutes of PEEP vs spontaneous breathing
- peripheral HbO2/DeoxyHb [ Time Frame: 1 min ]after three minutes of PEEP / PLB vs. spontaneous breathing
- cardiac output [ Time Frame: mean over 1 min ]after three min of PEEP vs. spontaneous breathing
- pattern of breathing (fR, VT, PETCO2) [ Time Frame: 1 min ]after three min of PEEP vs. spontaneous breathing
|Study Start Date:||February 2011|
healthy active subjects
with and without high altitude intolerance
Device: threshold PEEP
Various set of pressures : 0, 5, 10 cm H20; pursed lips breathing
Two types of procedures will be tested in a random order, interspaced by resting periods : threshold PEEP set at 5,10 and 15 cm of water and pursed leap breathing.
Subjects will be tested at rest, and during light exercise (30% of sea level predicted VO2max).
FiO2 will be set at 12.5% (4000 m). fc, VE, PETCO2, TA, ECG, cardiac output, and tissular oxygenation will be monitored.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01260428
|CHU de Grenoble|
|La Tronche, Isere, France, 38000|
|Principal Investigator:||Bernard Wuyam, MD, PhD||University Hospital, Grenoble|
|Study Director:||Samuel Vergès, PhD||Institut National de la Santé Et de la Recherche Médicale, France|
|Study Chair:||Hugo NESPOULET, MsC||Université Joseph Fourier|