Effects of Expiratory Pressure on Arterial Oxygenation During Hypoxia (hypex)
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|ClinicalTrials.gov Identifier: NCT01260428|
Recruitment Status : Unknown
Verified February 2012 by AGIR à Dom.
Recruitment status was: Recruiting
First Posted : December 15, 2010
Last Update Posted : February 28, 2012
|Condition or disease||Intervention/treatment|
|Hypoxia||Device: threshold PEEP|
Two types of procedures will be tested in a random order, interspaced by resting periods : threshold PEEP set at 5,10 and 15 cm of water and pursed leap breathing.
Subjects will be tested at rest, and during light exercise (30% of sea level predicted VO2max).
FiO2 will be set at 12.5% (4000 m). fc, VE, PETCO2, TA, ECG, cardiac output, and tissular oxygenation will be monitored.
|Study Type :||Observational|
|Estimated Enrollment :||20 participants|
|Official Title:||Arterial Oxygenation During Hypoxia : Effects of an Added Expiratory Resistance|
|Study Start Date :||February 2011|
healthy active subjects
with and without high altitude intolerance
Device: threshold PEEP
Various set of pressures : 0, 5, 10 cm H20; pursed lips breathing
- SpO2 [ Time Frame: mean over 1 minute ]after three minutes of PEEP vs spontaneous breathing
- peripheral HbO2/DeoxyHb [ Time Frame: 1 min ]after three minutes of PEEP / PLB vs. spontaneous breathing
- cardiac output [ Time Frame: mean over 1 min ]after three min of PEEP vs. spontaneous breathing
- pattern of breathing (fR, VT, PETCO2) [ Time Frame: 1 min ]after three min of PEEP vs. spontaneous breathing
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01260428
|Contact: Bernard Wuyam, MD, PhD||33 (0)4 76 76 93 03||BWuyam@chu-grenoble.fr|
|CHU de Grenoble||Recruiting|
|La Tronche, Isere, France, 38000|
|Contact: BERNARD WUYAM, MD? PhD (33) 04 76 76 93 03 BWuyam@chu-grenoble.fr|
|Contact: hugo nespoulet, Bsc 04 76 76 55 16 HNespoulet@chu-grenoble.fr|
|Principal Investigator: Bernard Wuyam, MD, PhD|
|Sub-Investigator: Samuel Vergès, PhD|
|Principal Investigator:||Bernard Wuyam, MD, PhD||University Hospital, Grenoble|
|Study Director:||Samuel Vergès, PhD||Institut National de la Santé Et de la Recherche Médicale, France|
|Study Chair:||Hugo NESPOULET, MsC||Université Joseph Fourier|