Quantification of Human Adipogenesis
This pilot study is using a novel technology to measure the rate of turnover of new fat cells. There is currently one active phase of this study. It involves a 1-day (no overnight) stay in the hospital, and 3 fat biopsies over a 6 month period. The study is ongoing, but is currently not enrolling new volunteers.
|Study Design:||Time Perspective: Prospective|
|Official Title:||Quantification of Human Adipogenesis|
- Quantifying human adipogenesis-counting the number of new fat cells. [ Time Frame: 4 weeks-7 months ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
Fat biopsy. Oral mucosal smear. White blood cells.
|Study Start Date:||December 2010|
|Estimated Study Completion Date:||February 2016|
|Estimated Primary Completion Date:||February 2015 (Final data collection date for primary outcome measure)|
18-49 year old healthy men and women. Free of significant chronic medical illness and illicit substance abuse. Body ass index from 20 to 27. Must be able to easily 'pinch an inch' of belly fat.
Biological: 15N-Thymidine, 2H-Water
Stable isotope 15N-thymidine, infused IV (15mg/hour) for 72 hours (phase 1 pilot).
Stable isotope 2H-water, ingested by mouth once per day for 3 days (phase 1 pilot) or 28 days (phase 2 pilot).
Please refer to this study by its ClinicalTrials.gov identifier: NCT01257997
|United States, Massachusetts|
|Brigham and Women's Hospital|
|Boston, Massachusetts, United States, 02115|
|Principal Investigator:||Matthew L Steinhauser, MD||Brigham and Women's Hospital|