Trial record 1 of 3 for:    CRONA
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Long-term Caloric Restriction and Cellular Aging Markers (CRONA)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01256840
Recruitment Status : Completed
First Posted : December 9, 2010
Results First Posted : October 13, 2017
Last Update Posted : October 13, 2017
Robert Wood Johnson Foundation
Information provided by (Responsible Party):
University of California, San Francisco

Brief Summary:
The purpose of this study is to see whether people who have restricted the number of calories they eat for a long period of time, compared to normal-eating and obese people, have markers of cellular aging that look younger.

Condition or disease

Study Type : Observational
Actual Enrollment : 71 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Caloric Restriction With Optimal Nutrition and Aging Study
Study Start Date : December 2010
Actual Primary Completion Date : August 2014
Actual Study Completion Date : August 2014

Calorie Restricting Group
Normal-eating controls
Obese comparison group

Primary Outcome Measures :
  1. Telomere Length [ Time Frame: One day ]
    This study is not a clinical trial, but the UCSF Committee on Human Research requires registration with It is a ONE TIME POINT study, where we get a simple blood draw from people from three groups - calorie restricting, normal eating, and obese. Therefore, there IS NO FOLLOW UP/time frame. The outcome measure is assessed on the day of the study. Telomere length is a marker of cellular aging and is used to understand how the cells are aging. We will investigate whether long-term caloric restriction is associated cross-sectionally with longer telomere length (less aging).

Biospecimen Retention:   Samples With DNA
Whole blood, serum.

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Community sample and Calorie Restriction Society

Inclusion Criteria:

  • Calorie restricting group: Self-reported caloric restriction for at least two years
  • Calorie restriction group: BMI below 23
  • Normal eating control: Normal eating (no history of caloric restriction) for two years
  • Normal eating control: BMI below 30
  • Obese comparison group: BMI above 30
  • Obese comparison group: Normal eating (no history of caloric restriction) for two years

Exclusion Criteria:

  • Regular smoker for the past six months

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01256840

United States, California
University of California
San Francisco, California, United States, 94118
Sponsors and Collaborators
University of California, San Francisco
Robert Wood Johnson Foundation
Principal Investigator: A. Janet Tomiyama, Ph.D. University of California, San Francisco