Transfusion Strategies in Weaning Patients (WTT)
Recruitment status was: Recruiting
The aim of this study is to determine, whether a liberal transfusion strategy is helpful to liberate patients from prolonged invasive mechanical ventilation.
Patients who are difficult to wean according to the criteria by Boles et al  are limited by the capacity of their respiratory muscles.
Improved oxygen delivery achieved by blood transfusions however is known to decrease the work of breathing  and thus in theory can improve weaning success .
This study is designed as a prospective, randomized, open labeled blinded End-point evaluation to test the hypothesis that a liberal transfusion strategy decreases the time needed for weaning.
- Boles, JM, J Bion, A Connors, M Herridge, B Marsh, C Melot, R Pearl, H Silverman, M Stanchina, A Vieillard-BaronandT Welte, Weaning from mechanical ventilation. Eur Respir J, 2007. 29(5): p. 1033.
- Schonhofer, B, M Wenzel, M GeibelandD Kohler, Blood transfusion and lung function in chronically anemic patients with severe chronic obstructive pulmonary disease. Crit Care Med, 1998. 26(11): p. 1824.
- Schonhofer, B, H BohrerandD Kohler, Blood transfusion facilitating difficult weaning from the ventilator. Anaesthesia, 1998. 53(2): p. 181.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Liberal Versus Restrictive Transfusion Management in Patients Being Weaned From Prolonged Mechanical Ventilation|
- Time to sucessfull weaning [ Time Frame: 14 days ] [ Designated as safety issue: No ]Time between randomisation an sucessfull liberation from invasive mechanical ventilation
- mortality [ Time Frame: within hospital ] [ Designated as safety issue: No ]mortality during the hospital stay
|Study Start Date:||December 2010|
|Estimated Study Completion Date:||February 2013|
|Estimated Primary Completion Date:||February 2013 (Final data collection date for primary outcome measure)|
No Intervention: restrictive transfusion
No transfusion given to correct anemia unless vital indication is given
Experimental: liberal transfusion
transfusions are given in single units until Hb is > 12 mg/dl
Other: blood transfusion
application of single units of red blood cell transfusions
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01256645
|Schmallenberg, NRW, Germany, 57392|
|Study Chair:||Dieter Köhler, Prof||FKKG|
|Principal Investigator:||Dominic Dellweg, M.D.||FKKG|
|Principal Investigator:||Thomas Barchfeld, M.D.||FKKG|