Impact of IPT With Sulfadoxin Pyrimetamin on Pregnant Women and Their Babies Outcomes in Peri-urban Areas of Bobo-Dioulasso(Burkina Faso)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01255605
Recruitment Status : Completed
First Posted : December 7, 2010
Last Update Posted : June 18, 2012
Information provided by (Responsible Party):
Dr Mamoudou Cisse, Centre Muraz

Brief Summary:
The purpose of this is to determine the impact of intermittent preventive treatment (IPT) with sulfadoxine-pyrimethamine (SP) on the morbidities associated with malaria in pregnant women and newborns in rural peri-urban areas of Bobo-Dioulasso, 5 years after its implemented.

Condition or disease
Malaria, Pregnancy

Detailed Description:
Malaria in pregnant women is a crucial issue in Burkina Faso. Faced with this problem, a strategy based on the use of treated nets and intermittent preventive treatment (IPT) based on sulfadoxine-pyrimethamine (SP) was adopted in 2005. Five years after its implementation, the investigators will check whether this strategy is still effective in the preventing maternal and congenital malaria on the one hand and maternal anemia, low birth weight and prematurity on the other hand.

Study Type : Observational
Actual Enrollment : 772 participants
Time Perspective: Cross-Sectional
Official Title: Impact of Intermittent Preventive Treatment (IPT) With Sulfadoxine-pyrimethamine (SP) on the Morbidities Associated With Malaria in Pregnant Women and Newborns in Peri-urban Areas of Bobo-Dioulasso, 5 Years After Its Adoption by the National Program for Fight Against Malaria in Burkina Faso.
Study Start Date : September 2010
Actual Study Completion Date : June 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Malaria
U.S. FDA Resources

Primary Outcome Measures :
  1. Peripheral and placental malaria [ Time Frame: Peripheral malaria : at antenatal clinics and at delivery. Placental malaria: at delivery ]
    The investigators will check if pregnant women have any malaria parasites by making a finger prick thick respectively at antenatal clinics and at delivery. A placental thin smear will be made at delivery.

Secondary Outcome Measures :
  1. Maternal anemia, congenital malaria,low birth weight, prematurity. [ Time Frame: Maternal anemia: at antenatal clinics and at delivery. Congenital malaria: at delivery. Low birth weight: at delivery. Prematurity: at delivery. ]

    The investigators will check pregnant women haemoglobin level.A level< 11g/dl will be considered as anemia.

    Congenital malaria will be assessed through cord blood smear. Birth weight <2500g will be considered as low birth weight. Prematurity designs any birth before 37 gestation weeks.

Biospecimen Retention:   Samples With DNA
The investigators make thick and thin blood smear and collect a few drops of blood on the 3MM paper Whatmann Schleicher-Schuell.

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Our study population is constitued by pregnant women coming for antenatal care or delivery in two peripheral heath facilities of Bobo-Dioulasso(Lafiabougou and Secteur 24).

Inclusion Criteria:

  • Residing in the health area of Lafiabougou or secteur 24
  • Having agreed to give free and informed consent

Exclusion Criteria:

  • Bleeding from during the pregnancy
  • eclampsia

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01255605

Burkina Faso
Institut Supérieur des Sciences de la Santé/Université Polytechnique de Bobo-Dioulasso
Bobo-Dioulasso, Houet, Burkina Faso, 1091
Sponsors and Collaborators
Université Polytechnique de Bobo-Dioulasso
Principal Investigator: Mamoudou Cisse, MD Centre MURAZ Research Institute

Responsible Party: Dr Mamoudou Cisse, Medical doctor, Centre Muraz Identifier: NCT01255605     History of Changes
Other Study ID Numbers: PIC/INSSA/UPB-01
First Posted: December 7, 2010    Key Record Dates
Last Update Posted: June 18, 2012
Last Verified: June 2012

Keywords provided by Dr Mamoudou Cisse, Centre Muraz:
Intermittent preventive treatment with sulfadoxin-pyrimethamine
in Bobo-Dioulasso peri-urban areas, 5 years after its implementation
Burkina Faso.

Additional relevant MeSH terms:
Protozoan Infections
Parasitic Diseases
Antiprotozoal Agents
Antiparasitic Agents
Anti-Infective Agents
Folic Acid Antagonists
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action