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The Correlation Between Genetic Polymorphism, Platelet Activity, Clopidogrel Responsiveness, and Serum Adipokine Concentration in Asian Acute Coronary Syndrome Patients

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified December 2010 by China Medical University Hospital.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01255267
First Posted: December 7, 2010
Last Update Posted: December 7, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
China Medical University Hospital
  Purpose
In this study, we evaluate the acute coronary syndrome patients to see if there is correlation between platelet activity, genetic polymorphism (CYP2C19 and ABCB1), serum adipokines level, and Clopidogrel responsiveness.

Condition
Acute Coronary Syndrome Chronic Coronary Artery Disease

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Correlation Between Genetic Polymorphism, Platelet Activity, , Clopidogrel Responsiveness, and Serum Adipokine Concentration in Asian Acute Coronary Syndrome Patients

Resource links provided by NLM:


Further study details as provided by China Medical University Hospital:

Groups/Cohorts
Acute coronary syndrome patients
Chronic coronary artery disease patients
Healthy control

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Acute coronary syndrome and chronic coronary artery diseae patients
Criteria

Inclusion Criteria:

  1. Age > 18 y/o
  2. Acute coronary syndrome patients
  3. Chronic coronary artery disease patients
  4. Healthy volunteers

Exclusion Criteria:

  1. Patient refusal
  2. Allergy to Clopidogrel
  3. Receive Gp IIb/IIIa inhibitor simultaneously
  4. Cancer history
  5. Severe renal and liver function impairment
  6. Coagulopathy
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01255267


Contacts
Contact: Yu-Chen Wang, MD 886-4-22052121 ext 2371 richard9250@yahoo.com.tw

Locations
Taiwan
China Medical University Hospital Recruiting
Taichung, Taiwan
Contact: Yu-Chen Wang, MD    886-4-22052121 ext 2371    richard9250@yahoo.com.tw   
Sponsors and Collaborators
China Medical University Hospital
  More Information

ClinicalTrials.gov Identifier: NCT01255267     History of Changes
Other Study ID Numbers: DMR99-IRB-041
First Submitted: December 6, 2010
First Posted: December 7, 2010
Last Update Posted: December 7, 2010
Last Verified: December 2010

Keywords provided by China Medical University Hospital:
Acute coronary syndrome and chronic coronary artery disease patients

Additional relevant MeSH terms:
Syndrome
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Acute Coronary Syndrome
Disease
Pathologic Processes
Heart Diseases
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases
Clopidogrel
Platelet Aggregation Inhibitors
Purinergic P2Y Receptor Antagonists
Purinergic P2 Receptor Antagonists
Purinergic Antagonists
Purinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs