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IOP Lowering Effects of Topical Anesthetics Used Frequently in the Ophthalmology Clinic

This study has been completed.
Information provided by (Responsible Party):
University of Nebraska Identifier:
First received: December 2, 2010
Last updated: June 13, 2012
Last verified: June 2012
The primary purpose of this study is to determine whether topical ophthalmic anesthetics lower the intraocular pressure in the eye.

Normal Tension Glaucoma

Study Type: Observational
Study Design: Time Perspective: Cross-Sectional
Official Title: Intraocular Pressure Lowering Effects of Topical Anesthetics Used Frequently in the Ophthalmology Clinic

Resource links provided by NLM:

Further study details as provided by University of Nebraska:

Primary Outcome Measures:
  • Measured pressures in subjects' eyes with and without anesthetics. [ Time Frame: 30 minutes ]

Enrollment: 43
Study Start Date: January 2011
Study Completion Date: April 2012
Primary Completion Date: April 2012 (Final data collection date for primary outcome measure)
  Show Detailed Description


Ages Eligible for Study:   19 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Subjects 19 years of age and older with normal eyes and with ocular disease.

Inclusion Criteria:

  • Subjects must be 19 years of age and older

Exclusion Criteria:

  • Corneal diseases including corneal transplants, corneal dystrophies, or trauma to the cornea that may prevent reliable tonometry of either eye.
  • Intolerant to topical Proparacaine and Benoxinate
  • Pregnant or nursing
  • 18 years of age and younger.
  • Physical limitation preventing ability to obtain reliable intraocular measurements (e.g. difficulty positioning subjects in front of the slit lamp or inability to keep eyes open during the intraocular pressure checks).
  Contacts and Locations
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Please refer to this study by its identifier: NCT01254149

United States, Nebraska
University of Nebraska Medical Center, Department of Ophthalmology
Omaha, Nebraska, United States, 68198
Sponsors and Collaborators
University of Nebraska
Principal Investigator: Nathan Welch, MD UNMC Department of Ophthalmology and Visual Sciences
  More Information

Responsible Party: University of Nebraska Identifier: NCT01254149     History of Changes
Other Study ID Numbers: 577-10-FB
Study First Received: December 2, 2010
Last Updated: June 13, 2012

Additional relevant MeSH terms:
Low Tension Glaucoma
Optic Nerve Diseases
Eye Diseases
Central Nervous System Depressants
Physiological Effects of Drugs processed this record on April 28, 2017