Saccadic Eye Movements Are Impaired In Glaucoma

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01254058
Recruitment Status : Enrolling by invitation
First Posted : December 6, 2010
Last Update Posted : July 28, 2017
Information provided by (Responsible Party):
St. Michael's Hospital, Toronto

Brief Summary:
The purpose of this study is to determine whether rapid eye movements called saccades are impaired in glaucoma, a neurodegenerative disease of visual pathways.

Condition or disease
Glaucoma, Open-Angle

Detailed Description:
Eye movements that quickly scan a visual scene are critical to a number of daily activities including driving. It is not known whether rapid eye movement called saccades, are altered in glaucoma.

Study Type : Observational
Actual Enrollment : 40 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Novel Vision Testing Paradigms for Patients With Glaucoma
Study Start Date : July 2010
Estimated Primary Completion Date : November 2017
Estimated Study Completion Date : December 2017

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Glaucoma

Glaucoma Group
Age-Matched Controls

Primary Outcome Measures :
  1. Delay in saccades [ Time Frame: April 2014 ]

Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
19 glaucoma patients and 21 age-matched controls will be identified and consented.

Inclusion Criteria:

  • Ages from 40-80 years. Primary open angle glaucoma is defined by characteristic glaucomatous optic nerve head findings and the presence of corresponding visual field deficits in one or both eyes. All control subjects will be age-matched, with no ocular medical or surgical history, and a completely normal eye examination. Age-matched controls will be recruited from local hospital personnel and accompanying relatives.

Exclusion criteria:

  • Any patient with a history of other eye disease, neurological disease or neurodegenerative disorder, or history of incisional ocular surgery within the previous month will be excluded.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01254058

Canada, Ontario
St. Michael's Hospital
Toronto, Ontario, Canada, M5B 1W8
Sponsors and Collaborators
St. Michael's Hospital, Toronto
Principal Investigator: Neeru Gupta, MD, PhD St. Michael's Hospital, Toronto

Publications of Results:
Other Publications:
Responsible Party: St. Michael's Hospital, Toronto Identifier: NCT01254058     History of Changes
Other Study ID Numbers: REB 06-056
First Posted: December 6, 2010    Key Record Dates
Last Update Posted: July 28, 2017
Last Verified: July 2017

Additional relevant MeSH terms:
Glaucoma, Open-Angle
Ocular Hypertension
Eye Diseases