Bile Acid-induced GLP-secretion. A Study in Cholecystectomized Subjects
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|ClinicalTrials.gov Identifier: NCT01251510|
Recruitment Status : Completed
First Posted : December 2, 2010
Last Update Posted : January 23, 2013
The goal of the present project is to unravel the importance of bile acid-induced GLP-1 secretion (via the G protein-coupled receptor TGR5) in human physiology.
In the present study the investigators examine the GLP-1 secretion in healthy subjects and cholecystectomised patients. Thereby the investigators aim to show, that cholecystectomised patients have reduced bileflow after a meal, and as a consequence exhibit a diminished GLP-1 response as compared to healthy subjects.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||20 participants|
|Official Title:||Bile Acid-induced GLP-secretion. A Study in Cholecystectomized Subjects|
|Study Start Date :||October 2010|
|Actual Primary Completion Date :||June 2011|
|Actual Study Completion Date :||June 2011|
|Type 2 diabetes|
- GLP-1 secretion [ Time Frame: Postprandial ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01251510
|Gentofte University Hospital|
|Hellerup, Denmark, 2900|
|Principal Investigator:||David P. Sonne, MD||Gentofte Hospital, University of Copenhagen|