Effect of Bariatric Surgery on Gut Hormones Production and Cure of Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2DM) is a relevant public health problem and obesity has been associated as the major risk factor. Roux-en-Y gastric bypass is an effective method to treat severe obesity, and its metabolic benefits can lead to early and complete remission of T2DM, even before a considerable weight loss. We have hypothesized that intestinal anatomic changes may change intestinal genes expression related to glycemic control. The knowledge of mechanisms mediating the glycemic control after Roux-en-Y gastric bypass and it site of action in bowel may eventually help to develop alternative, less invasive and safer surgery for the treatment of T2DM, as well as drug development for the newly targets identified.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Changes in Gene Expression of Intestinal Tissue From Type 2 Diabetes Patients Submitted to Roux-en-Y Gastric Bypass|
- Patient Selection [ Time Frame: 2013 ] [ Designated as safety issue: No ]10 patients fully completed with all biological samples colected in the preoperative and postoperative periods (gastrointestinal tissue). RNA extraction of gastrointestinal samples is being performed.
|Study Start Date:||July 2010|
|Estimated Study Completion Date:||July 2016|
|Estimated Primary Completion Date:||December 2015 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01251016
|Clinics Hospital of the University of São Paulo Medical School||Recruiting|
|São Paulo, Brazil, 05403-000|
|Contact: Clinics Hospital FMUSP +55 11 30696000 firstname.lastname@example.org|