Type 2 Diabetes Mellitus Collaborative Genetic Study on Non-aboriginal Taiwanese (T2D2)
|ClinicalTrials.gov Identifier: NCT01250639|
Recruitment Status : Unknown
Verified November 2010 by China Medical University Hospital.
Recruitment status was: Recruiting
First Posted : December 1, 2010
Last Update Posted : December 1, 2010
|Condition or disease|
|Type 2 Diabetes Mellitus|
This study is a cooperative project between Academia Sinica (AS), China Medical University Hospital (CMUH) and Chiayi Christian Hospital (CCH) and aims to identify genetic components associated with type 2 diabetes mellitus (T2DM), which is significant for the population of non-aboriginal Taiwanese. AS provides funding, designs the study protocol, and coordinates the project, including subject recruitment, collection of phenotype information and bio-specimen and quality assurance. CMUH and CCH are the study sites and are responsible for subject screening and recruitment, bio-specimen collection and packaging as well as phenotypic information collection. The study objective is to carry out a collaborative association study on T2DM in non-aboriginal Taiwanese.
A genome-wide case-control association study will be adopted. Approximately five thousand of T2DM subjects whose age is equal to or above twenty will be recruited by study physicians in the out-patient-department in CMUH and CCH. In addition, relatives of T2DM subjects with a positive family history, in which at least three family members are affected with T2DM within five generations, will be recruited by study nurses. An age-, sex-, and ethnicity-matched control will be selected randomly from the Cell Bank and Genetic Database on Non-Aboriginal Taiwanese. After obtaining informed consent, the medical history questionnaire and family background will be completed by the subjects. The subjects will be invited for a health check-up which include blood pressure, body weight, body height, waist circumference and hip circumference, as well as an ophthalmic check-up. A 15 ml of blood will be drawn from the subject for measurements of Cholesterol, HDLc, LDLc, TG, Fasting Plasma Glucose, Insulin, HbA1c, CBC without differential count, Electrolytes (Ca2+ , Na+, K+, Cl-), BUN, Creatinine, SGOT, SGPT, C-peptide, Uric Acid and CRP, as well as DNA extraction. A urine sample collection will also be requested from the subject for evaluation of urine protein, ketone body, glucose, micro albumine and creatinine.
This genome-wide association study aims to investigate the disease causing variants/genes of T2DM and diabetic subphenotypes as well as the underlying mechanisms in T2DM pathogenesis. Hopefully, early diagnostic markers and new therapies will be developed based on the genetic etiology and toward the personalized medicine in the future.
|Study Type :||Observational|
|Estimated Enrollment :||5000 participants|
|Observational Model:||Case Control|
|Official Title:||Type 2 Diabetes Mellitus Collaborative Genetic Study Room|
|Study Start Date :||August 2010|
|Estimated Primary Completion Date :||December 2013|
|Estimated Study Completion Date :||December 2013|
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01250639
|Contact: Fuu-Jen Tsai, PHD||866-4-22052121 ext email@example.com|
|China Medical University Hospital||Recruiting|
|Taichung, Taiwan, 40447|
|Contact: Fuu-Jen Tsai, PHD 886-4-22052121 ext 2041 firstname.lastname@example.org|
|Principal Investigator:||Fuu-Jen Tsai, PHD||Division of Metabolism and Endocrinology|