Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

SNAP VS BIS(OAA/S) Scale During a Sedation Regimen With and Without Ketamine

This study has been terminated.
(Monitor manufacturer stopped marketing plan for the product.)
Information provided by (Responsible Party):
Gildasio De Oliveira, Northwestern University Identifier:
First received: August 3, 2010
Last updated: August 18, 2014
Last verified: August 2014

The study question: Does the SNAP-Index (SI) correlates better with the OASS than the BIS Monitor during sedation with ketamine?

The study hypothesis: Since the SNAP II monitor seems to be more responsive during emergence of anesthesia, it will have a better correlation with the OASS than the BIS monitor with the use of ketamine.

Condition Intervention
Drug: Ketamine group

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Care Provider, Investigator)
Primary Purpose: Basic Science
Official Title: A Comparison Between the Correlation of the Bispectral Index Versus Snap Index With the Observer's Assessment of Alertness and Sedation (OAA/S) Scale During a Sedation Regimen With and Without Ketamine

Resource links provided by NLM:

Further study details as provided by Northwestern University:

Primary Outcome Measures:
  • TcCO2 Above 50 [ Time Frame: Intraoperative, an average of about 1 and 1/2 hours. ]
    % Time Tosca Monitor (TcCO2) above 50. A TcCo2 above 50 is indicative of hypoventilation.

Enrollment: 25
Study Start Date: August 2010
Study Completion Date: May 2012
Primary Completion Date: May 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Ketamine Group
ketamine bolus of 0.25mg/kg followed by an infusion set at 1.5 mcg /kg/min.
Drug: Ketamine group
ketamine bolus of 0.25mg/kg followed by an infusion set at 1.5 mcg /kg/min.
No Intervention: No ketamine
No ketamine added to anesthesia regimen


Ages Eligible for Study:   18 Years to 64 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Age : 18-64 years
  • ASA : I-III
  • Procedure : Breast or gynecological surgery
  • Anesthesia :Monitored anesthesia care

Exclusion Criteria:

  • Pregnancy
  • Breast Feeding
  • Body Mass Index >35kg/m2
  • Drug or Alcohol abuse
  • Use anticonvulsants
  • History of CVA
  • Drop-out criteria:

    • Patient or surgeon request
    • Conversion to general anesthesia
    • Inability to obtain data from both monitors
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01250418

United States, Illinois
Northwestern Memorial Hospital
Chicago, Illinois, United States, 60611
Sponsors and Collaborators
Northwestern University
Principal Investigator: Gildasio DeOliveira, MD Northwestern University
  More Information


Responsible Party: Gildasio De Oliveira, Gildasio De Oliveira, M.D. Principal Investigator, Northwestern University Identifier: NCT01250418     History of Changes
Other Study ID Numbers: STU00031783
Study First Received: August 3, 2010
Results First Received: July 23, 2014
Last Updated: August 18, 2014

Keywords provided by Northwestern University:
Bispectral Index

Additional relevant MeSH terms:
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anesthetics, Dissociative
Anesthetics, Intravenous
Anesthetics, General
Central Nervous System Depressants
Excitatory Amino Acid Antagonists
Excitatory Amino Acid Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action processed this record on May 23, 2017