Expression of Optic Atrophy Type 1 (OPA1) Protein in Lung Adenocarcinoma

The recruitment status of this study is unknown because the information has not been verified recently.
Verified November 2010 by China Medical University Hospital.
Recruitment status was  Recruiting
Information provided by:
China Medical University Hospital Identifier:
First received: November 24, 2010
Last updated: November 26, 2010
Last verified: November 2010
Optic atrophy type 1(OPA1) is a nuclear dynamin-related GTPase, targeted to the inner mitochondrial membrane, which plays a role in mitochondrial fusion. Mitochondria fusion is associated with process of apoptosis. . OPA1 plays an important role in the mitochondrial bioenergetics and mitochondrial networks. The changes in mitochondrial shape and mitochondrial bioenergetics may be cause of the disease. In this study, we investigate the expression of OPA1 in lung adenocarcinoma (LADC) cells and tissue.

Lung Adenocarcinoma

Study Type: Observational
Study Design: Time Perspective: Retrospective

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Further study details as provided by China Medical University Hospital:

Estimated Enrollment: 100
Study Start Date: August 2010

Ages Eligible for Study:   25 Years to 85 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Between January 2006 and December 2008, we will retrospectively enroll 100 consecutive LADC patients who were admitted to the Department of Thoracic Surgery of China Medical University Hospital.

Inclusion Criteria:

  • We will collect paraffin blocked resected lung tissue samples from stage I~IIIa non-small cell lung cancer patients (age, 40~80 years old) who received lobectomy of the affected lung.

Exclusion Criteria:

  • History of uremia, other malignant disease, and liver cirrhosis
  • History of pneumonia and pulmonary tuberculosis
  • History of long period of medications.
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Please refer to this study by its identifier: NCT01249053

Fang Hsin Yuan Recruiting
Taichung, Taiwan, 404
Contact: Hsin-Yuan Fang, MD    +886422052121 ext 1638   
Sponsors and Collaborators
China Medical University Hospital
  More Information

Responsible Party: Fang Hsin-Yuan/Director, China Medical University Hospital Identifier: NCT01249053     History of Changes
Other Study ID Numbers: DMR99-IRB-062 
Study First Received: November 24, 2010
Last Updated: November 26, 2010
Health Authority: Taiwan: Institutional Review Board

Keywords provided by China Medical University Hospital:
lung adenocarcinomas
Expression of optic atrophy type 1 (OPA1) protein in lung adenocarcinoma

Additional relevant MeSH terms:
Lung Neoplasms
Optic Atrophy, Autosomal Dominant
Cranial Nerve Diseases
Eye Diseases
Eye Diseases, Hereditary
Genetic Diseases, Inborn
Heredodegenerative Disorders, Nervous System
Lung Diseases
Metabolic Diseases
Mitochondrial Diseases
Neoplasms by Histologic Type
Neoplasms by Site
Neoplasms, Glandular and Epithelial
Nervous System Diseases
Neurodegenerative Diseases
Optic Atrophies, Hereditary
Optic Atrophy
Optic Nerve Diseases
Respiratory Tract Diseases
Respiratory Tract Neoplasms
Thoracic Neoplasms processed this record on May 30, 2016